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    eco Establishment of cohesion [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38812, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ecoprovided by FlyBase
    Official Full Name
    Establishment of cohesionprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035766
    Locus tag
    Dmel_CG8598
    See related
    AllianceGenome:FB:FBgn0035766
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8598; deco; Deco; Dmel\CG8598; Eco; ECO; Eco1
    Summary
    Predicted to enable peptide-lysine-N-acetyltransferase activity. Involved in mitotic sister chromatid cohesion. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in Roberts syndrome and lung adenocarcinoma. Orthologous to several human genes including ESCO1 (establishment of sister chromatid cohesion N-acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eco in Genome Data Viewer
    Location:
    65F5-65F5; 3-20 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7335442..7339340, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7328542..7332440, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mutagen-sensitive 312 Neighboring gene wurmchen 1 Neighboring gene wurmchen 2 Neighboring gene lark Neighboring gene Cln7 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rejuvenation of meiotic cohesion in oocytes during prophase I is required for chiasma maintenance and accurate chromosome segregation. Weng KA, et al. PLoS Genet, 2014 Sep. PMID 25211017, Free PMC Article
    2. Effects of sister chromatid cohesion proteins on cut gene expression during wing development in Drosophila. Dorsett D, et al. Development, 2005 Nov. PMID 16207752, Free PMC Article
    3. Cohesin, gene expression and development: lessons from Drosophila. Dorsett D. Chromosome Res, 2009. PMID 19308700, Free PMC Article
    4. Using Drosophila to identify naturally occurring genetic modifiers of amyloid beta 42- and tau-induced toxicity. Yang M, et al. G3 (Bethesda), 2023 Aug 30. PMID 37311212, Free PMC Article
    5. Two putative acetyltransferases, san and deco, are required for establishing sister chromatid cohesion in Drosophila. Williams BC, et al. Curr Biol, 2003 Dec 2. PMID 14653991

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    establishment of cohesion
    Names
    CG8598-PA
    CG8598-PB
    drosophila eco1
    eco-PA
    eco-PB
    NP_648106.1
    NP_729236.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7335442..7339340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139849.3 → NP_648106.1  establishment of cohesion, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648106.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1K9, Q6AWN5, Q95RU6, Q9VS50
      UniProtKB/TrEMBL
      H1UUH1
      Related
      FBpp0076592
      Conserved Domains (3) summary
      cd04301
      Location:945 → 1008
      NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
      pfam13878
      Location:839 → 878
      zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
      pfam13880
      Location:982 → 1043
      Acetyltransf_13; ESCO1/2 acetyl-transferase

    2. NM_168201.2 → NP_729236.2  establishment of cohesion, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729236.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1K9, Q6AWN5, Q95RU6, Q9VS50
      UniProtKB/TrEMBL
      H1UUH1
      Conserved Domains (3) summary
      cd04301
      Location:945 → 1008
      NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
      pfam13878
      Location:839 → 878
      zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
      pfam13880
      Location:982 → 1043
      Acetyltransf_13; ESCO1/2 acetyl-transferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS50.1 Q9VS50

    Gene LinkOut

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