Arpc1 Actin-related protein 2/3 complex, subunit 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Arpc1provided by FlyBase
Official Full Name: Actin-related protein 2/3 complex, subunit 1provided by FlyBase
Primary source: FLYBASE:FBgn0001961
Locus tag: Dmel_CG8978
See related: AllianceGenome:FB:FBgn0001961
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 34Dd; ARC-P41; arc41; Arc41; ArcP41; arpc1; arpC1; ArpC1; ARPC1; ARPC1/p41; BG:DS00941.7; br32; CG8978; D-sop2; Dmel\CG8978; Dsop2; DSop2; l(2)34Dd; l(2)br32; l(2)Sop2; p41; p42; sop; sop2; Sop2; sop2/arc41; Spo2
Summary: Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including axon development; nuclear envelope budding; and positive regulation of filopodium assembly. Located in cytosol and nuclear lamina. Colocalizes with nuclear envelope. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; larval muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; myelodysplastic syndrome; and pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A) and ARPC1B (actin related protein 2/3 complex subunit 1B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 34D1-34D1; 2-49 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (13827941..13829741, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (13827941..13829741, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Shaping Drosophila eggs: unveiling the roles of Arpc1 and cpb in morphogenesis.
Title: Shaping Drosophila eggs: unveiling the roles of Arpc1 and cpb in morphogenesis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in Arp2/3 complex-mediated actin nucleation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal fasciculation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear envelope budding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pseudocleavage involved in syncytial blastoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	IEA Inferred from Electronic Annotation more info
part_of Arp2/3 protein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of Arp2/3 protein complex	NAS Non-traceable Author Statement more info	PubMed
part_of Arp2/3 protein complex	TAS Traceable Author Statement more info	PubMed
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear lamina	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Actin-related protein 2/3 complex, subunit 1

Names: Arpc1-PA; Arpc1-PB; CG8978-PA; CG8978-PB; lethal(2)34Dd; profilin 2; suppressor of; suppressor of profilin 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

13827941..13829741 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165063.3 → NP_723845.1 Actin-related protein 2/3 complex, subunit 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723845.1

Status: REVIEWED

UniProtKB/TrEMBL

O97182

Related

FBpp0080146

Conserved Domains (3) summary

COG2319
Location:3 → 181

WD40; WD40 repeat [General function prediction only]

sd00039
Location:14 → 53

7WD40; WD40 repeat [structural motif]

cl02567
Location:3 → 236

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_057248.5 → NP_476596.1 Actin-related protein 2/3 complex, subunit 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476596.1

Status: REVIEWED

UniProtKB/TrEMBL

O97182

Related

FBpp0080147

Conserved Domains (3) summary

COG2319
Location:3 → 181

WD40; WD40 repeat [General function prediction only]

sd00039
Location:14 → 53

7WD40; WD40 repeat [structural motif]

cl02567
Location:3 → 236

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...