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    CSN7 COP9 signalosome subunit 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CSN7provided by FlyBase
    Official Full Name
    COP9 signalosome subunit 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0028836
    Locus tag
    Dmel_CG2038
    See related
    AllianceGenome:FB:FBgn0028836
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2038; CH7; csn7; Csn7; CSN7b; Dch7; Dmel\CG2038
    Summary
    Involved in several processes, including female germ-line stem cell population maintenance; germarium-derived cystoblast division; and male germ-line cyst encapsulation. Located in nuclear periphery. Part of COP9 signalosome. Is expressed in adult head. Orthologous to human COPS7A (COP9 signalosome subunit 7A) and COPS7B (COP9 signalosome subunit 7B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CSN7 in Genome Data Viewer
    Location:
    44C6-44C6; 2-58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8421033..8428577)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4308538..4316082)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Larval cuticle protein 1 Neighboring gene Larval cuticle protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The COP9 signalosome (CSN): an evolutionary conserved proteolysis regulator in eukaryotic development. Schwechheimer C. Biochim Biophys Acta, 2004 Nov 29. PMID 15571808
    2. COP9 signalosome subunit 5 (CSN5/Jab1) regulates the development of the Drosophila immune system: effects on Cactus, Dorsal and hematopoiesis. Harari-Steinberg O, et al. Genes Cells, 2007 Feb. PMID 17295838
    3. Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5. Gemmill RM, et al. Oncogene, 2005 May 12. PMID 15735686
    4. The COP9 signalosome is essential for development of Drosophila melanogaster. Freilich S, et al. Curr Biol, 1999 Oct 21. PMID 10531038
    5. Protein competition switches the function of COP9 from self-renewal to differentiation. Pan L, et al. Nature, 2014 Oct 9. PMID 25119050

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in COP9 signalosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived cystoblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male germ-line cyst encapsulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deneddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COP9 signalosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of COP9 signalosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    COP9 signalosome subunit 7
    Names
    CG2038-PA
    COP9 complex homolog subunit 7
    CSN7-PA
    drosophila COP9 signalosome homolog 7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8421033..8428577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136535.3 → NP_610379.2  COP9 signalosome subunit 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610379.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NLA1, Q9V4S8
      UniProtKB/TrEMBL
      N0A733
      Related
      FBpp0087821
      Conserved Domains (1) summary
      smart00753
      Location:96 → 185
      PAM; PCI/PINT associated module
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V4S8.2 Q9V4S8

    Gene LinkOut

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