U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    brv2 brivido-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39932, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    brv2provided by FlyBase
    Official Full Name
    brivido-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036712
    Locus tag
    Dmel_CG16793
    See related
    AllianceGenome:FB:FBgn0036712
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Brivido 2; Brivido2; Brv-2; Brv2; CG16793; CT33194; Dmel\CG16793
    Summary
    Predicted to enable calcium channel activity. Involved in cellular response to cold and detection of temperature stimulus involved in thermoception. Predicted to be active in membrane. Is expressed in several structures, including anlage in statu nascendi; central brain anlage in statu nascendi; and dorsal ectoderm anlage. Orthologous to human PKD1L2 (polycystin 1 like 2 (gene/pseudogene)); PKD1L3 (polycystin 1 like 3, transient receptor potential channel interacting); and PKDREJ (polycystin family receptor for egg jelly). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See brv2 in Genome Data Viewer
    Location:
    74A5-74A5; 3-45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17342050..17344696, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17335150..17337796, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Proline-CGG 2-2 Neighboring gene uncharacterized protein Neighboring gene Myoinhibiting peptide precursor Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Correcting locomotion dependent observation biases in thermal preference of Drosophila. Giraldo D, et al. Sci Rep, 2019 Mar 8. PMID 30850647, Free PMC Article
    2. The coding of temperature in the Drosophila brain. Gallio M, et al. Cell, 2011 Feb 18. PMID 21335241, Free PMC Article
    3. Temperature sensation in Drosophila. Barbagallo B, et al. Curr Opin Neurobiol, 2015 Oct. PMID 25616212, Free PMC Article
    4. Ionotropic Receptors Specify the Morphogenesis of Phasic Sensors Controlling Rapid Thermal Preference in Drosophila. Budelli G, et al. Neuron, 2019 Feb 20. PMID 30654923, Free PMC Article
    5. Feeling Hot and Cold: Thermal Sensation in Drosophila. Li K, et al. Neurosci Bull, 2017 Jun. PMID 27995563, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cellular response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of temperature stimulus involved in thermoception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    brivido-2
    Names
    Brivido-2
    CG16793-PA
    CG16793-PB
    brv2-PA
    brv2-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17342050..17344696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275053.1 → NP_001261982.1  brivido-2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFT4
      Conserved Domains (1) summary
      pfam08016
      Location:147 → 574
      PKD_channel; Polycystin cation channel

    2. NM_140713.2 → NP_648970.2  brivido-2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648970.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8Z2, Q9VVF6
      Related
      FBpp0075004
      Conserved Domains (1) summary
      pfam08016
      Location:169 → 596
      PKD_channel; Polycystin cation channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFT4 M9PFT4
    Q8T8Z2 Q8T8Z2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous