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    Shab Shaker cognate b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38352, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Shabprovided by FlyBase
    Official Full Name
    Shaker cognate bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262593
    Locus tag
    Dmel_CG43128
    See related
    AllianceGenome:FB:FBgn0262593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1066; CG43128; CG9965; Dmel\CG43128; dShab; Kv2; K[[v]]2; shab; shb
    Old locus tag
    Dmel_CG1066; Dmel_CG9965
    Summary
    Enables delayed rectifier potassium channel activity. Involved in several processes, including larval locomotory behavior; positive regulation of circadian sleep/wake cycle, sleep; and regulation of synaptic activity. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in alcohol dependence; developmental and epileptic encephalopathy 26; epilepsy; and retinal cone dystrophy 3B. Orthologous to several human genes including KCNB2 (potassium voltage-gated channel subfamily B member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Shab in Genome Data Viewer
    Location:
    63A1-63A2; 3-5 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2895017..2959579)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2895017..2959579)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44531 Neighboring gene spatzle 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 63a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Celecoxib and ion channels: a story of unexpected discoveries. Frolov RV, et al. Eur J Pharmacol, 2014 May 5. PMID 24630832
    2. Characterization of five RNA editing sites in Shab potassium channels. Ryan MY, et al. Channels (Austin), 2008 May-Jun. PMID 18836299, Free PMC Article
    3. A-to-I RNA editing alters less-conserved residues of highly conserved coding regions: implications for dual functions in evolution. Yang Y, et al. RNA, 2008 Aug. PMID 18567816, Free PMC Article
    4. Inhibition of delayed rectifier potassium channels and induction of arrhythmia: a novel effect of celecoxib and the mechanism underlying it. Frolov RV, et al. J Biol Chem, 2008 Jan 18. PMID 17984087
    5. Mutational analysis of the Shab-encoded delayed rectifier K(+) channels in Drosophila. Hegde P, et al. J Biol Chem, 1999 Jul 30. PMID 10419540

    See all (135) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Shab is a typical K channel that excludes Na
      Title: K⁺-dependent selectivity and external Ca²⁺ block of Shab K⁺ channels.
    2. Upon illumination, the delayed rectifier current mediated by Shab channels Drosophila photoreceptors was specifically increased.
      Title: Light-dependent modulation of Shab channels via phosphoinositide depletion in Drosophila photoreceptors.
    3. observations highlight crucial control of nerve terminal excitability by Shaker & Shab channels to confer temporal patterns of synaptic transmission & suggest participation of these channels in activity-dependent synaptic plasticity
      Title: Distinct frequency-dependent regulation of nerve terminal excitability and synaptic transmission by IA and IK potassium channels revealed by Drosophila Shaker and Shab mutations.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    shaker cognate b
    Names
    CG43128-PA
    CG43128-PB
    CG43128-PC
    CG43128-PH
    CG43128-PI
    CG43128-PJ
    CG43128-PK
    CG43128-PL
    CG43128-PM
    CG43128-PN
    Shab-PA
    Shab-PB
    Shab-PC
    Shab-PH
    Shab-PI
    Shab-PJ
    Shab-PK
    Shab-PL
    Shab-PM
    Shab-PN
    shaker

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2895017..2959579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274416.1 → NP_001261345.1  shaker cognate b, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261345.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE38
      Conserved Domains (4) summary
      smart00225
      Location:309 → 416
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:501 → 700
      Ion_trans; Ion transport protein
      pfam02214
      Location:309 → 408
      BTB_2; BTB/POZ domain
      pfam07885
      Location:613 → 696
      Ion_trans_2; Ion channel

    2. NM_001202108.2 → NP_001189037.1  shaker cognate b, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189037.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRZ7
      Conserved Domains (4) summary
      smart00225
      Location:309 → 416
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:501 → 700
      Ion_trans; Ion transport protein
      pfam02214
      Location:309 → 408
      BTB_2; BTB/POZ domain
      pfam07885
      Location:613 → 696
      Ion_trans_2; Ion channel

    3. NM_001043115.3 → NP_001036580.1  shaker cognate b, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036580.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76805, P17970, Q9I7T9, Q9I7U0
      UniProtKB/TrEMBL
      Q0E8I8
      Conserved Domains (4) summary
      smart00225
      Location:309 → 416
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:501 → 700
      Ion_trans; Ion transport protein
      pfam02214
      Location:309 → 408
      BTB_2; BTB/POZ domain
      pfam07885
      Location:613 → 696
      Ion_trans_2; Ion channel

    4. NM_167967.4 → NP_728783.1  shaker cognate b, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728783.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76805, P17970, Q9I7T9, Q9I7U0
      Related
      FBpp0293731
      Conserved Domains (4) summary
      smart00225
      Location:309 → 416
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:501 → 700
      Ion_trans; Ion transport protein
      pfam02214
      Location:309 → 408
      BTB_2; BTB/POZ domain
      pfam07885
      Location:613 → 696
      Ion_trans_2; Ion channel

    5. NM_079170.6 → NP_523894.2  shaker cognate b, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523894.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76805, P17970, Q9I7T9, Q9I7U0
      Related
      FBpp0293732
      Conserved Domains (4) summary
      smart00225
      Location:309 → 416
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:501 → 700
      Ion_trans; Ion transport protein
      pfam02214
      Location:309 → 408
      BTB_2; BTB/POZ domain
      pfam07885
      Location:613 → 696
      Ion_trans_2; Ion channel

    6. NM_001202110.2 → NP_001189039.1  shaker cognate b, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189039.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE38
      Conserved Domains (4) summary
      smart00225
      Location:309 → 416
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:501 → 700
      Ion_trans; Ion transport protein
      pfam02214
      Location:309 → 408
      BTB_2; BTB/POZ domain
      pfam07885
      Location:613 → 696
      Ion_trans_2; Ion channel

    7. NM_001202109.2 → NP_001189038.1  shaker cognate b, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189038.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRU9
      Conserved Domains (4) summary
      smart00225
      Location:309 → 416
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:501 → 700
      Ion_trans; Ion transport protein
      pfam02214
      Location:309 → 408
      BTB_2; BTB/POZ domain
      pfam07885
      Location:613 → 696
      Ion_trans_2; Ion channel

    8. NM_001259656.2 → NP_001246585.1  shaker cognate b, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246585.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76805, P17970, Q9I7T9, Q9I7U0
      UniProtKB/TrEMBL
      M9ND32
      Conserved Domains (4) summary
      smart00225
      Location:309 → 416
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:501 → 700
      Ion_trans; Ion transport protein
      pfam02214
      Location:309 → 408
      BTB_2; BTB/POZ domain
      pfam07885
      Location:613 → 696
      Ion_trans_2; Ion channel

    9. NM_001259655.2 → NP_001246584.1  shaker cognate b, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246584.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76805, P17970, Q9I7T9, Q9I7U0
      UniProtKB/TrEMBL
      M9NFJ6
      Conserved Domains (4) summary
      smart00225
      Location:309 → 416
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:501 → 700
      Ion_trans; Ion transport protein
      pfam02214
      Location:309 → 408
      BTB_2; BTB/POZ domain
      pfam07885
      Location:613 → 696
      Ion_trans_2; Ion channel

    10. NM_001104015.4 → NP_001097485.3  shaker cognate b, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097485.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNI9
      Conserved Domains (4) summary
      smart00225
      Location:309 → 416
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:501 → 700
      Ion_trans; Ion transport protein
      pfam02214
      Location:309 → 408
      BTB_2; BTB/POZ domain
      pfam07885
      Location:613 → 696
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNI9 A8JNI9
    M9MRU9 M9MRU9
    M9MRZ7 M9MRZ7
    M9ND32 M9ND32
    M9NFJ6 M9NFJ6
    M9PE38 M9PE38
    P17970.2 P17970
    Q0E8I8 Q0E8I8
    Q95T71 Q95T71

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