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    Faa Fumarylacetoacetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45577, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Faaprovided by FlyBase
    Official Full Name
    Fumarylacetoacetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016013
    Locus tag
    Dmel_CG14993
    See related
    AllianceGenome:FB:FBgn0016013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14993; dfaa; Dmel\CG14993; l(3)64Al; l(3)SH11
    Summary
    Predicted to enable fumarylacetoacetase activity. Predicted to be involved in L-phenylalanine catabolic process; homogentisate catabolic process; and tyrosine catabolic process. Is expressed in embryonic Malpighian tubule; embryonic dorsal epidermis; and embryonic pars intercerebralis. Human ortholog(s) of this gene implicated in tyrosinemia type I. Orthologous to human FAH (fumarylacetoacetate hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Faa in Genome Data Viewer
    Location:
    64A5-64A5; 3-10 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4072032..4073954, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4072032..4073954, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene disembodied Neighboring gene wishful thinking Neighboring gene uncharacterized protein Neighboring gene Glutamic acid decarboxylase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Presynaptic glutamic acid decarboxylase is required for induction of the postsynaptic receptor field at a glutamatergic synapse. Featherstone DE, et al. Neuron, 2000 Jul. PMID 10939332
    2. wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila. Aberle H, et al. Neuron, 2002 Feb 14. PMID 11856529
    3. The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels. Chávez VM, et al. Development, 2000 Oct. PMID 10976044
    4. Tyrosine Metabolism Pathway Is Downregulated in Dopaminergic Neurons with LRRK2 Overexpression in Drosophila. Cheng J, et al. Int J Mol Sci, 2023 Oct 25. PMID 37958569, Free PMC Article
    5. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Parkhitko AA, et al. Elife, 2020 Dec 15. PMID 33319750, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fumarylacetoacetase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fumarylacetoacetase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homogentisate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tyrosine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fumarylacetoacetase
    Names
    CG14993-PA
    Faa-PA
    NP_524830.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4072032..4073954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080091.4 → NP_524830.2  fumarylacetoacetase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524830.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0P3, Q9VZI8
      Related
      FBpp0073134
      Conserved Domains (3) summary
      PLN02856
      Location:1 → 414
      PLN02856; fumarylacetoacetase
      pfam01557
      Location:121 → 409
      FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family
      pfam09298
      Location:17 → 115
      FAA_hydrolase_N; Fumarylacetoacetase N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZI8 Q9VZI8

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