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    CG14715 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41403, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14715provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037930
    Locus tag
    Dmel_CG14715
    See related
    AllianceGenome:FB:FBgn0037930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM09283; BcDNA:RH50927; Dmel\CG14715; FKBP13
    Summary
    Predicted to enable FK506 binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding. Located in endomembrane system. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; and visceral mesoderm derivative. Orthologous to human FKBP2 (FKBP prolyl isomerase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14715 in Genome Data Viewer
    Location:
    86E15-86E15; 3-51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11674221..11674923)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7499943..7500645)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Elongator complex protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 12 Neighboring gene uncharacterized protein Neighboring gene Heme oxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside. Kawasaki H, et al. Gene, 2017 May 30. PMID 28286087
    2. Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster. Ghartey-Kwansah G, et al. BMC Dev Biol, 2018 Mar 27. PMID 29587629, Free PMC Article
    3. FKBP14 is an essential gene that regulates Presenilin protein levels and Notch signaling in Drosophila. van de Hoef DL, et al. Development, 2013 Feb. PMID 23318643
    4. Identification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly. Favrin G, et al. Sci Rep, 2013 Dec 16. PMID 24336499, Free PMC Article
    5. Genome-wide analysis of genes associated with moderate and high DDT resistance in Drosophila melanogaster. Qiu X, et al. Pest Manag Sci, 2013 Aug. PMID 23371854

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FK506 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14715-PA
    NP_650101.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11674221..11674923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141844.4 → NP_650101.1  uncharacterized protein Dmel_CG14715 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650101.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGK3
      Related
      FBpp0081899
      Conserved Domains (1) summary
      pfam00254
      Location:34 → 127
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGK3 Q9VGK3

    Gene LinkOut

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