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    CG42327 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41401, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42327provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259227
    Locus tag
    Dmel_CG42327
    See related
    AllianceGenome:FB:FBgn0259227
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.710; CG14713; CG14714; CG18479; Dmel\CG42327
    Old locus tag
    Dmel_CG14713; Dmel_CG14714
    Summary
    Predicted to enable transmembrane receptor protein tyrosine phosphatase activity. Predicted to be involved in motor neuron axon guidance and signal transduction. Is expressed in several structures, including adult head; embryonic/larval epidermis; embryonic/larval fat body; larval peripheral nervous system; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in colorectal cancer and esophagus squamous cell carcinoma. Orthologous to human PTPRK (protein tyrosine phosphatase receptor type K); PTPRM (protein tyrosine phosphatase receptor type M); and PTPRT (protein tyrosine phosphatase receptor type T). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42327 in Genome Data Viewer
    Location:
    86E13-86E15; 3-51 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11656149..11673974)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7481871..7499696)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44137 Neighboring gene C-terminal Src kinase Neighboring gene Elongator complex protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complex protein interactions mediate Drosophila Lar function in muscle tissue. Kawakami J, et al. PLoS One, 2022. PMID 35622884, Free PMC Article
    2. Computational analysis of protein tyrosine phosphatases: practical guide to bioinformatics and data resources. Andersen JN, et al. Methods, 2005 Jan. PMID 15588990
    3. Gain-of-function screen for genes that affect Drosophila muscle pattern formation. Staudt N, et al. PLoS Genet, 2005 Oct. PMID 16254604, Free PMC Article
    4. A Drosophila-centric view of protein tyrosine phosphatases. Hatzihristidis T, et al. FEBS Lett, 2015 Apr 13. PMID 25771859
    5. Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Bakal C, et al. Science, 2008 Oct 17. PMID 18927396, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42327-PE
    NP_001036706.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11656149..11673974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043241.3 → NP_001036706.2  uncharacterized protein Dmel_CG42327 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036706.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2VEF6, Q0KI81
      Conserved Domains (2) summary
      cd00047
      Location:1134 → 1415
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:1134 → 1415
      Y_phosphatase; Protein-tyrosine phosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KI81 Q0KI81

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