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    SmydA-2 SET and MYND domain containing, arthropod-specific, member 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40075, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SmydA-2provided by FlyBase
    Official Full Name
    SET and MYND domain containing, arthropod-specific, member 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036839
    Locus tag
    Dmel_CG18136
    See related
    AllianceGenome:FB:FBgn0036839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18136; Dmel\CG18136
    Summary
    Predicted to enable histone deacetylase binding activity. Predicted to be involved in negative regulation of gene expression. Predicted to be active in nucleus. Is expressed in adult head; larval muscle system; and larval somatic muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SmydA-2 in Genome Data Viewer
    Location:
    75F2-75F2; 3-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19000985..19003252, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18994085..18996352, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene naked cuticle Neighboring gene long non-coding RNA:CR45940 Neighboring gene Accessory gland protein 76A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of the feedback antagonist naked cuticle by Wingless signaling. Chang JL, et al. Dev Biol, 2008 Sep 15. PMID 18585374, Free PMC Article
    2. Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species. Calpena E, et al. PLoS One, 2015. PMID 26230726, Free PMC Article
    3. A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. Thompson EC, et al. PLoS One, 2008 Aug 20. PMID 18714374, Free PMC Article
    4. DEAF-1 function is essential for the early embryonic development of Drosophila. Veraksa A, et al. Genesis, 2002 Jun. PMID 12112874
    5. Comparative genomic analysis of SET domain family reveals the origin, expansion, and putative function of the arthropod-specific SmydA genes as histone modifiers in insects. Jiang F, et al. Gigascience, 2017 Jun 1. PMID 28444351, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone deacetylase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SET and MYND domain containing, arthropod-specific, member 2
    Names
    CG18136-PA
    SmydA-2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19000985..19003252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140827.3 → NP_649084.1  SET and MYND domain containing, arthropod-specific, member 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649084.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLS5, Q9VVV8
      Related
      FBpp0074807
      Conserved Domains (2) summary
      smart00317
      Location:246 → 291
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam01753
      Location:9 → 46
      zf-MYND; MYND finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVV8 Q9VVV8

    Gene LinkOut

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