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    Echs1 Enoyl-CoA hydratase, short chain 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36536, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Echs1provided by FlyBase
    Official Full Name
    Enoyl-CoA hydratase, short chain 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033879
    Locus tag
    Dmel_CG6543
    See related
    AllianceGenome:FB:FBgn0033879
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18645; CG6543; Dmel\CG6543
    Summary
    Predicted to enable 3-hydroxypropionyl-CoA dehydratase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; germline cell; and gut section. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in mitochondrial short-chain enoyl-CoA hydratase 1 deficiency. Orthologous to human ECHS1 (enoyl-CoA hydratase, short chain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Echs1 in Genome Data Viewer
    Location:
    50C6-50C6; 2-68 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13852947..13854331, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9740452..9741836, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-9379 stem loop Neighboring gene antisense RNA:CR44367 Neighboring gene uncharacterized protein Neighboring gene tumbleweed

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A neuron-glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis. Haynes PR, et al. Nat Neurosci, 2024 Apr. PMID 38360946, Free PMC Article
    2. Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. Terhzaz S, et al. J Biol Chem, 2006 Jul 7. PMID 16670086
    3. Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections. Von Ohlen T, et al. Infect Immun, 2012 Oct. PMID 22851751, Free PMC Article
    4. Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse. Song T, et al. Cell Res, 2023 Jun. PMID 37055592, Free PMC Article
    5. Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity. Ma S, et al. Aging Cell, 2018 Aug. PMID 29671950, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3-hydroxypropionyl-CoA dehydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enoyl-CoA hydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Enoyl-CoA hydratase, short chain 1
    Names
    CG6543-PA
    CG6543-PB
    Echs1-PA
    Echs1-PB
    NP_610910.1
    NP_725332.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13852947..13854331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137066.4 → NP_610910.1  Enoyl-CoA hydratase, short chain 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610910.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JR58
      Related
      FBpp0086769
      Conserved Domains (1) summary
      cl23717
      Location:37 → 294
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    2. NM_166014.3 → NP_725332.1  Enoyl-CoA hydratase, short chain 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725332.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JR58
      Related
      FBpp0086770
      Conserved Domains (1) summary
      cl23717
      Location:37 → 294
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JR58 Q7JR58

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