ab abrupt [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: abprovided by FlyBase
Official Full Name: abruptprovided by FlyBase
Primary source: FLYBASE:FBgn0264442
Locus tag: Dmel_CG43860
See related: AllianceGenome:FB:FBgn0264442
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Ab; B2149; CG32830; CG43860; CG4807; clu; Dmel\CG43860; l(2)k02807; ptd
Old locus tag: Dmel_CG32830; Dmel_CG4807
Summary: Involved in several processes, including border follicle cell migration; muscle attachment; and nervous system development. Located in nucleus. Is expressed in several structures, including anterior-posterior subdivision of organism; epidermis; ganglia; imaginal disc; and precursor cell of the stomatogastric nervous system. Orthologous to human ZBTB22 (zinc finger and BTB domain containing 22). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 32E1-32E2; 2-44 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (11210678..11261080)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (11210678..11261080)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings define a miR-306-abrupt regulatory axis that controls wing and haltere size
Title: The microRNA-306/abrupt regulatory axis controls wing and haltere growth in Drosophila.
ab is essential for proper wing vein patterning both in Tribolium and Drosophila.
Title: Comparative developmental analysis of Drosophila and Tribolium reveals conserved and diverged roles of abrupt in insect wing evolution.
The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively.
Title: Sensory-neuron subtype-specific transcriptional programs controlling dendrite morphogenesis: genome-wide analysis of Abrupt and Knot/Collier.
Abrupt is a repressor of ecdysone signalling and border-cell migration in ovarian follicles. Abrupt represents a node of integration for steroid hormone and JAK-STAT signals.
Title: Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt.
The dendritic branching can be suppressed by neuronal subtype-specific transcription factors in a cell-autonomous and dosage-dependent manner.
Title: BTB/POZ-zinc finger protein abrupt suppresses dendritic branching in a neuronal subtype-specific and dosage-dependent manner.
Ab endows characteristics of dendritic morphogenesis of the class I ofdendritic arborization (da)neurons.
Title: Development of morphological diversity of dendrites in Drosophila by the BTB-zinc finger protein abrupt.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in axon choice point recognition	TAS Traceable Author Statement more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic target recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: abrupt

Names: CG43860-PA; CG43860-PB; CG43860-PD; CG43860-PE; CG43860-PF; ab-PA; ab-PB; ab-PD; ab-PE; ab-PF; clueless; parted

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

11210678..11261080

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057214.5 → NP_476562.1 abrupt, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476562.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1JHF4, Q24174, Q86NP4, Q9VKI1

Related

FBpp0304816

Conserved Domains (4) summary

smart00225
Location:104 → 189

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00020
Location:546 → 567

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:93 → 189

BTB; BTB/POZ domain

pfam05605
Location:545 → 597

zf-Di19; Drought induced 19 protein (Di19), zinc-binding
NM_057215.5 → NP_476563.1 abrupt, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476563.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24174

Related

FBpp0304818

Conserved Domains (4) summary

smart00225
Location:104 → 189

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00020
Location:536 → 557

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:93 → 189

BTB; BTB/POZ domain

pfam05605
Location:535 → 587

zf-Di19; Drought induced 19 protein (Di19), zinc-binding
NM_001169481.2 → NP_001162952.1 abrupt, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162952.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24174

Conserved Domains (4) summary

smart00225
Location:104 → 189

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00020
Location:536 → 557

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:93 → 189

BTB; BTB/POZ domain

pfam05605
Location:535 → 587

zf-Di19; Drought induced 19 protein (Di19), zinc-binding
NM_001273449.1 → NP_001260378.1 abrupt, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260378.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PB99

Conserved Domains (3) summary

smart00225
Location:104 → 189

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:825 → 845

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:93 → 189

BTB; BTB/POZ domain
NM_001273450.1 → NP_001260379.1 abrupt, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260379.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24174

Conserved Domains (4) summary

smart00225
Location:104 → 189

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00020
Location:536 → 557

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:93 → 189

BTB; BTB/POZ domain

pfam05605
Location:535 → 587

zf-Di19; Drought induced 19 protein (Di19), zinc-binding