amn amnesiac [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: amnprovided by FlyBase
Official Full Name: amnesiacprovided by FlyBase
Primary source: FLYBASE:FBgn0086782
Locus tag: Dmel_CG11937
See related: AllianceGenome:FB:FBgn0086782
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Amn; Anm; CG11937; chpd; dAmn; Dmel\CG11937; Drm-amn; EP(X)1442; PACAP; PACAP-38; PACAP-like; Pacap38; PACAP38; PACAP38-like
Summary: Predicted to enable neuropeptide hormone activity. Involved in several processes, including behavioral response to ethanol; learning or memory; and perineurial glial growth. Located in extracellular space. Is expressed in several structures, including brain; lateral longitudinal fascicle; mushroom body modulatory input neurons; synaptic neuropil domain; and synaptic neuropil subdomain. Used to study alcohol use disorder. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 18F4-19A2; 1-64 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19886108..19890060, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19780141..19784093, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila Middle-Term Memory: Amnesiac is Required for PKA Activation in the Mushroom Bodies, a Function Modulated by Neprilysin 1.
Title: Drosophila Middle-Term Memory: Amnesiac is Required for PKA Activation in the Mushroom Bodies, a Function Modulated by Neprilysin 1.
Amnesiac is required for normal development of dorsal paired medial neurons and in adult mushroom body for memory formation.
Title: Amnesiac Is Required in the Adult Mushroom Body for Memory Formation.
These results provide compelling evidence that amn is a novel genetic component of the mechanism that regulates thermal nociception in Drosophila.
Title: The amnesiac gene is involved in the regulation of thermal nociception in Drosophila melanogaster.
amn is required in initiation and maintenance of sleep.
Title: amnesiac regulates sleep onset and maintenance in Drosophila melanogaster.
brain functions from knockouts and mutants (REVIEW)
Title: Higher brain functions of PACAP and a homologous Drosophila memory gene amnesiac: insights from knockouts and mutants.
Choice behavior in Drosophila involves central nervous learning and memory operating via cyclic AMP signaling pathways
Title: Cyclic AMP-dependent memory mutants are defective in the food choice behavior of Drosophila.
Age-related memory impairment in flies results from a specific decrease in amn-dependent middle-term memory.
Title: Aging specifically impairs amnesiac-dependent memory in Drosophila.
provides support for functional homology between human PACAP-38 and the amn gene product in Drosophilas
Title: Modulation of L-type calcium channels in Drosophila via a pituitary adenylyl cyclase-activating polypeptide (PACAP)-mediated pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables neuropeptide hormone activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in anesthesia-resistant memory	TAS Traceable Author Statement more info	PubMed
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP-mediated signaling	TAS Traceable Author Statement more info	PubMed
involved_in courtship behavior	TAS Traceable Author Statement more info	PubMed
NOT involved_in learning	TAS Traceable Author Statement more info	PubMed
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	TAS Traceable Author Statement more info	PubMed
involved_in male courtship behavior	TAS Traceable Author Statement more info	PubMed
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuropeptide signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in olfactory learning	IDA Inferred from Direct Assay more info	PubMed
involved_in perineurial glial growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: amnesiac

Names: CG11937-PA; amn-PA; cheap date; cheapdate; pituitary adenylyl cyclase-activating polypeptide; pituitary adenylyl cyclase-activating polypeptide-like