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    fliI flightless I [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33110, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fliIprovided by FlyBase
    Official Full Name
    flightless Iprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000709
    Locus tag
    Dmel_CG1484
    See related
    AllianceGenome:FB:FBgn0000709
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    15; BcDNA:LD21753; CG1484; CT3691; DCA3-19; Dmel\CG1484; EN3; fli; fli I; fli-I; Fli-I; FLI-I; fltI; fltO; l(1)18-80; l(1)19Fd; l(1)ESHS53; l(1)W-2; lDCB2-19; sdby; w-2; W2
    Summary
    Predicted to enable actin filament binding activity; calcium ion binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in adult somatic muscle development; gastrulation involving germ band extension; and myofibril assembly. Is active in Z disc. Is expressed in furrow canal; indirect flight muscle cell; and organism. Used to study obesity. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human FLII (FLII actin remodeling protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fliI in Genome Data Viewer
    Location:
    19F5-19F5; 1-65 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21339741..21345088)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21210768..21216115)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tweety Neighboring gene dodo Neighboring gene penguin Neighboring gene small optic lobes

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular and mutational analysis of a gelsolin-family member encoded by the flightless I gene of Drosophila melanogaster. de Couet HG, et al. Genetics, 1995 Nov. PMID 8582612, Free PMC Article
    2. Flightless-I Controls Fat Storage in Drosophila. Park JE, et al. Mol Cells, 2018 Jun. PMID 29890821, Free PMC Article
    3. The gelsolin-related flightless I protein is required for actin distribution during cellularisation in Drosophila. Straub KL, et al. J Cell Sci, 1996 Jan. PMID 8834811
    4. The flightless I protein localizes to actin-based structures during embryonic development. Davy DA, et al. Immunol Cell Biol, 2000 Aug. PMID 10947868
    5. The novel flightless-I gene brings together two gene families, actin-binding proteins related to gelsolin and leucine-rich-repeat proteins involved in Ras signal transduction. Claudianos C, et al. Mol Biol Evol, 1995 May. PMID 7739382

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The actin polymerization factor Diaphanous and the actin severing protein Flightless I collaborate to regulate sarcomere size.
      Title: The actin polymerization factor Diaphanous and the actin severing protein Flightless I collaborate to regulate sarcomere size.
    2. The results showed that Drosophila FliI regulates the expression of metabolic genes, and that dysregulation of the transcription controlled by FliI gives rise to metabolic stress and problems in the development and physiology of Drosophila.
      Title: Potential involvement of Drosophila flightless-1 in carbohydrate metabolism.
    3. effect of FliI protein on actin remodelling is a vital part of cellular motility, contraction and adhesion. Exact signaling pathways and mechanisms underpinning FliI effects in wound healing are yet to be fully identified[review]
      Title: Flightless I: an actin-remodelling protein and an important negative regulator of wound repair.
    4. Drosophila flightless-I gene, highly conserved in C. elegans and humans, is involved in gastrulation and muscle degeneration
      Title: The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adult somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gastrulation involving germ band extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    flightless I
    Names
    CG1484-PA
    Flightless-I
    fliI-PA
    flightless
    flightless-1
    gluful-2
    lgluful-2
    section 15
    standby

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21339741..21345088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080358.3 → NP_525097.1  flightless I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525097.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24020, Q24088, Q9VRH0
      Related
      FBpp0076893
      Conserved Domains (9) summary
      cd11280
      Location:618 → 706
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1037 → 1141
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:491 → 602
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:1151 → 1250
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:729 → 828
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd00116
      Location:70 → 304
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:338 → 360
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:102 → 124
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:101 → 159
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24020.1 Q24020

    Gene LinkOut

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