ftz fushi tarazu [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ftzprovided by FlyBase
Official Full Name: fushi tarazuprovided by FlyBase
Primary source: FLYBASE:FBgn0001077
Locus tag: Dmel_CG2047
See related: AllianceGenome:FB:FBgn0001077
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS07876.1; CG2047; Dm-ftz; Dm-Ftz; Dmel\CG2047; Dmftz; DmFtz; Ftz; FTZ; l(3)84Ag; Ual
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including germ cell migration; gonadal mesoderm development; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including germ layer; glial cell; larval CNS neuron; parasegment; and somatic precursor cell. Orthologous to human HOXC5 (homeobox C5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 84A6-84A6; 3-48 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (6864324..6866244)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (2690046..2691966)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ftz upstream element drives late ftz stripes but is not required for regulation of Ftz target genes.
Title: The ftz upstream element drives late ftz stripes but is not required for regulation of Ftz target genes.
Precisely timed regulation of enhancer activity defines the binary expression pattern of Fushi tarazu in the Drosophila embryo.
Title: Precisely timed regulation of enhancer activity defines the binary expression pattern of Fushi tarazu in the Drosophila embryo.
The fushi tarazu zebra element is not required for Drosophila viability or fertility.
Title: The fushi tarazu zebra element is not required for Drosophila viability or fertility.
Comparative analysis of enhancers containing Ftz/Ftz-F1 binding sites that were or were not bona fide targets in vivo suggested that GAF negatively regulates enhancers that contain Ftz/Ftz-F1 binding sites but are not actually utilized.
Title: Activation of Ftz-F1-Responsive Genes through Ftz/Ftz-F1 Dependent Enhancers.
Evolutionary acquisition of the LXXLL motif specialized Ftz for segmentation, while strengthening the Ftz/Ftz-F1 interaction led to degeneration of the YPWM motif and loss of homeotic activity.
Title: Cofactor-interaction motifs and the cooption of a homeotic Hox protein into the segmentation pathway of Drosophila melanogaster.
Contrasting responses of different downstream targets to Runt in the presence or absence of Ftz is thus central to the combinatorial logic of the pair-rule to segment-polarity transition.
Title: Ftz modulates Runt-dependent activation and repression of segment-polarity gene transcription.
FTZ(delta151-209) is a hyperactive FTZ molecule; the region encompassing amino acids 151-209 of FTZ is required in some manner for repression of FTZ activity
Title: Low-level ectopic expression of Fushi tarazu in Drosophila melanogaster results in ftz(Ual/Rpl)-like phenotypes and rescues ftz phenotypes.
influences Ftz-F1 activity by interacting with its AF-2 domain in a manner that mimics a nuclear receptor coactivator
Title: The nuclear receptor Ftz-F1 and homeodomain protein Ftz interact through evolutionarily conserved protein domains.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate specification	TAS Traceable Author Statement more info	PubMed
involved_in central nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonadal mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in periodic partitioning by pair rule gene	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segmentation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fushi tarazu

Names: CG2047-PA; Fushi-Tarazu; Ultra-abdominal-like; ftz-PA; fushitarazu

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

6864324..6866244

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058150.3 → NP_477498.1 fushi tarazu [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477498.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O96929, P02835, Q4V6Y3, Q9V3W3

Related

FBpp0081139

Conserved Domains (2) summary

pfam00046
Location:257 → 310

Homeobox; Homeobox domain

pfam03867
Location:1 → 248

FTZ; Fushi tarazu (FTZ), N-terminal region