gsb gooseberry [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: gsbprovided by FlyBase
Official Full Name: gooseberryprovided by FlyBase
Primary source: FLYBASE:FBgn0001148
Locus tag: Dmel_CG3388
See related: AllianceGenome:FB:FBgn0001148
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BSH-9; BSH9; BSH9c2; CG3388; Dmel\CG3388; Gsb; gsb-2; gsb-d; Gsb-d; GSB-D; gsb-distal; gsbBSH9; gsbd; l(2)01155; l(2)gsb
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of synaptic activity; salivary gland morphogenesis; and segment polarity determination. Located in cytoplasm and nucleus. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior subdivision of organism; genital disc; germ layer; and neuroblasts. Human ortholog(s) of this gene implicated in Waardenburg syndrome (multiple); alveolar rhabdomyosarcoma; congenital myopathy 19; and craniofacial-deafness-hand syndrome. Orthologous to human PAX3 (paired box 3) and PAX7 (paired box 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (25061964..25064643)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20949487..20952166)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ventral cord development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain