Sod1 Superoxide dismutase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sod1provided by FlyBase
Official Full Name: Superoxide dismutase 1provided by FlyBase
Primary source: FLYBASE:FBgn0003462
Locus tag: Dmel_CG11793
See related: AllianceGenome:FB:FBgn0003462
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 24492; CG11793; cSod; cSOD; Cu; Cu-Zn SOD; Cu-Zn-SOD; Cu/Zn sod; Cu/Zn Sod; Cu/Zn SOD; Cu/Zn superoxide dismutase; Cu/Zn-SOD; Cu/ZnSOD; CuSOD; CuZn SOD; CuZn-SOD; CuZn-SOD1; CuZnSOD; Cu[2+]/Zn[2+]SOD; Dmel\CG11793; dsod; dsod1; dSod1; dSOD1; G; l(3)108; l(3)68Af'; l(3)G; Mn SOD; sod; Sod; SOD; sod-1; Sod-1; SOD-1; SOD-c; sod1; SOD1; SODC_DROME; To; To-1; Zn Sod; Zn SOD; Zn-SOD; ZN-SOD; Zn-SOD1; ZnSod
Summary: Enables protein homodimerization activity and superoxide dismutase activity. Involved in several processes, including determination of adult lifespan; positive regulation of mitophagy; and regulation of terminal button organization. Located in peroxisome. Is expressed in several structures, including Malpighian tubule; digestive system; germline cell; gonad; and salivary gland. Used to study amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 1. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 68A7-68A7; 3-34 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11112281..11113740, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11105381..11106840, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Age-dependent degeneration of an identified adult leg motor neuron in a Drosophila SOD1 model of ALS.
Title: Age-dependent degeneration of an identified adult leg motor neuron in a Drosophila SOD1 model of ALS.
Amyotrophic Lateral Sclerosis Genes in Drosophila melanogaster.
Title: Amyotrophic Lateral Sclerosis Genes in Drosophila melanogaster.
SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1.
Title: SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1.
an interesting interplay between SOD1, ROS and mTOR signalling that regulates the dynamics of VAP aggregation, is reported.
Title: SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis.
the cytosolic SOD-null syndrome is largely consistent across sex and genetic background, but also significantly influenced by both.
Title: Sex and Genetic Background Influence Superoxide Dismutase (cSOD)-Related Phenotypic Variation in Drosophila melanogaster.
The functional SOD1 and SOD2 genes knockout and their overexpression in neurons and glial tissue increase the sensitivity of Drosophila melanogaster to oxidative stress conditions.
Title: [Influence of tissue-specific superoxide dismutase genes expression in brain cells on Drosophila melanogaster sensitivity to oxidative stress and viability].
Expression of zinc-deficient human superoxide dismutase in Drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction.
Title: Expression of zinc-deficient human superoxide dismutase in Drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction.
curcumin increases mean lifespan of Drosophila via regulating gene expression of the key enzyme SOD and reducing accumulation of MDA and lipid peroxidation.
Title: Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila.
The activity of carbohydrate metabolizing enzymes, lipid and triglyceride concentration, and steady state NADPH:NADP(+) in SOD1-null and control transgenic rescue flies, was analysed.
Title: A model of oxidative stress management: moderation of carbohydrate metabolizing enzymes in SOD1-null Drosophila melanogaster.
switching SOD1-deficient flies from normoxia into hypoxia fails to alter their mortality
Title: Hypoxia rescues early mortality conferred by superoxide dismutase deficiency.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables superoxide dismutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide dismutase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in superoxide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISM Inferred from Sequence Model more info	PubMed
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: superoxide dismutase 1

Names: CG11793-PA; Cu, Zn superoxide dismutase; Cu-Zn superoxide dismutase; Cu/Zn superoxide; Cu/Zn superoxide dismutase; Cu/Zn-Superoxide dismutase; CuZn superoxide dismutase; CuZn-superoxide dismutase; CuZn-superoxide dismutase (SOD)1; CuZnSOD; Cu[2+] Zn[2+] superoxide dismutase; Cu[2+]Zn[2+] superoxide dismutase; Mn superoxide dismutase; SOD 1; Sod1-PA; complementation group G; copper and zinc SOD; copper-zinc superoxide; copper-zinc superoxide dismutase; cytoplasmic Cu/ZnSOD; dismutase; super oxide dismutase; superoxidase dismutase; superoxide dismutase; superoxide dismutases 1; superoxide dismutatase; superoxide-dismutase; superoxido dismutase; tetrazolium oxidase; tetrazolium oxidase-1

NP_476735.1

EC 1.15.1.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

11112281..11113740 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057387.5 → NP_476735.1 superoxide dismutase 1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476735.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P61851, Q27770

Related

FBpp0075958

Conserved Domains (1) summary

cl00891
Location:2 → 150

Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...