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    Ptp99A Protein tyrosine phosphatase 99A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43469, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptp99Aprovided by FlyBase
    Official Full Name
    Protein tyrosine phosphatase 99Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004369
    Locus tag
    Dmel_CG11516
    See related
    AllianceGenome:FB:FBgn0004369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11515; CG11516; CG11517; CG2005; CT6383; Dmel\CG11516; dptp99A; Dptp99A; DPTP99A; DPTP[[99A]]; ptp99A; PTP99A; R-PTP 99A
    Summary
    Enables protein tyrosine phosphatase activity. Involved in defasciculation of motor neuron axon and motor neuron axon guidance. Located in axon. Is expressed in several structures, including adult fat body; adult head; ganglia; larval CNS neuron; and neuron projection bundle. Orthologous to several human genes including PTPRG (protein tyrosine phosphatase receptor type G). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ptp99A in Genome Data Viewer
    Location:
    99A7-99B1; 3-98 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29377646..29487131)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25203368..25312853)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45547 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44022 Neighboring gene uncharacterized protein Neighboring gene Spase 12-subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a receptor-class phosphotyrosine phosphatase gene expressed on central nervous system axons in Drosophila melanogaster. Hariharan IK, et al. Proc Natl Acad Sci U S A, 1991 Dec 15. PMID 1662390, Free PMC Article
    2. Inter-domain interactions influence the stability and catalytic activity of the bi-domain protein tyrosine phosphatase PTP99A. Madan LL, et al. Biochim Biophys Acta, 2012 Aug. PMID 22595398
    3. Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS. Yang XH, et al. Cell, 1991 Nov 15. PMID 1657401
    4. Axon guidance: motor-way madness. Stoker AW. Curr Biol, 1996 Jul 1. PMID 8835859
    5. Tyrosine phosphorylation and axon guidance: of mice and flies. Desai CJ, et al. Curr Opin Neurobiol, 1997 Feb. PMID 9039791

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. During embryonic development of the mushroom body, Ptp99A is expressed within an expanded core region including somewhat older axons.
      Title: Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 29406674-29407871 mobile_element_type = transposon:jockey{}1451

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonal defasciculation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in defasciculation of motor neuron axon IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein tyrosine phosphatase 99A
    Names
    CG11516-PA
    CG11516-PB
    CG11516-PC
    CG11516-PF
    CG11516-PG
    Ptp99A-PA
    Ptp99A-PB
    Ptp99A-PC
    Ptp99A-PF
    Ptp99A-PG
    NP_001189309.1
    NP_476816.1
    NP_651691.4
    NP_733288.1
    NP_996302.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29377646..29487131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143434.5 → NP_651691.4  protein tyrosine phosphatase 99A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651691.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAL5
      Conserved Domains (4) summary
      smart00194
      Location:646 → 911
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:676 → 911
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:342 → 437
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:249 → 331
      fn3; Fibronectin type III domain

    2. NM_206579.3 → NP_996302.1  protein tyrosine phosphatase 99A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996302.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35832, Q59DT5, Q7KRW3, Q8IMK9, Q9VAL3
      Conserved Domains (3) summary
      smart00194
      Location:490 → 755
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:520 → 755
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:171 → 281
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. NM_170409.3 → NP_733288.1  protein tyrosine phosphatase 99A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733288.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35832, Q59DT5, Q7KRW3, Q8IMK9, Q9VAL3
      Conserved Domains (3) summary
      smart00194
      Location:475 → 740
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:505 → 740
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:171 → 266
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    4. NM_057468.3 → NP_476816.1  protein tyrosine phosphatase 99A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476816.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35832, Q59DT5, Q7KRW3, Q8IMK9, Q9VAL3
      Conserved Domains (3) summary
      smart00194
      Location:475 → 740
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:505 → 740
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:171 → 266
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    5. NM_001202380.2 → NP_001189309.1  protein tyrosine phosphatase 99A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189309.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JDF4
      Conserved Domains (2) summary
      smart00194
      Location:100 → 365
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:130 → 365
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JDF4 A0A0B4JDF4
    P35832.2 P35832
    Q9VAL5 Q9VAL5

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