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    Gad1 Glutamic acid decarboxylase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38484, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gad1provided by FlyBase
    Official Full Name
    Glutamic acid decarboxylase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0004516
    Locus tag
    Dmel_CG14994
    See related
    AllianceGenome:FB:FBgn0004516
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14994; dgad1; dGad1; DGad1; DGAD1; Dm-GDC; Dmel\CG14994; gad; Gad; GAD; GAD-1; gad1; GAD1; GAD[[1]]; Glb; l(3)64An; l(3)SH10
    Summary
    Enables glutamate decarboxylase activity. Involved in several processes, including carboxylic acid metabolic process; olfactory learning; and synapse organization. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; brain; ellipsoid body layer; neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; developmental and epileptic encephalopathy 89; diabetes mellitus (multiple); and drug psychosis. Orthologous to human GAD1 (glutamate decarboxylase 1) and GAD2 (glutamate decarboxylase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gad1 in Genome Data Viewer
    Location:
    64A5-64A5; 3-10 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4074077..4088744, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4074077..4088744, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene wishful thinking Neighboring gene uncharacterized protein Neighboring gene Fumarylacetoacetase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fermitin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Decoding odor quality and intensity in the Drosophila brain. Strutz A, et al. Elife, 2014 Dec 16. PMID 25512254, Free PMC Article
    2. The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning. Liu X, et al. Nat Neurosci, 2009 Jan. PMID 19043409, Free PMC Article
    3. Transcriptional organization of a Drosophila glutamic acid decarboxylase gene. Newby LM, et al. J Neurochem, 1993 Mar. PMID 8436982
    4. Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses. Romano G, et al. Sci Rep, 2018 Jan 29. PMID 29379112, Free PMC Article
    5. Internal state affects local neuron function in an early sensory processing center to shape olfactory behavior in Drosophila larvae. Odell SR, et al. Sci Rep, 2022 Sep 21. PMID 36131078, Free PMC Article

    See all (196) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila CNS.
      Title: TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila CNS.
    2. Negative developmental regulation of GAD can be overridden by drugs known to elevate intracellular free [Ca2+]
      Title: In developing Drosophila neurones the production of gamma-amino butyric acid is tightly regulated downstream of glutamate decarboxylase translation and can be influenced by calcium.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate decarboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables glutamate decarboxylase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in glutamate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    glutamic acid decarboxylase 1
    Names
    CG14994-PA
    CG14994-PB
    CG14994-PC
    CG14994-PD
    GABA synthetase
    Gad1-PA
    Gad1-PB
    Gad1-PC
    Gad1-PD
    glutamate decarboxylase
    glutamatic acid decarboxylase
    glutamic acid decarboxylase
    glutamic acid decarboxylase-1
    vesicular glutamic acid decarboxylase
    NP_001261396.1
    NP_523914.2
    NP_728930.1
    NP_728931.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4074077..4088744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168055.2 → NP_728930.1  glutamic acid decarboxylase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728930.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1G1, P20228, Q9VZI7
      UniProtKB/TrEMBL
      M9PH99
      Related
      FBpp0073131
      Conserved Domains (1) summary
      pfam00282
      Location:64 → 434
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    2. NM_001274467.1 → NP_001261396.1  glutamic acid decarboxylase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261396.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1G1, P20228, Q9VZI7
      UniProtKB/TrEMBL
      M9PH99
      Conserved Domains (1) summary
      pfam00282
      Location:64 → 434
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    3. NM_079190.3 → NP_523914.2  glutamic acid decarboxylase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523914.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1G1, P20228, Q9VZI7
      UniProtKB/TrEMBL
      M9PH99
      Related
      FBpp0073132
      Conserved Domains (1) summary
      pfam00282
      Location:64 → 434
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    4. NM_168056.2 → NP_728931.1  glutamic acid decarboxylase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728931.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1G1, P20228, Q9VZI7
      UniProtKB/TrEMBL
      M9PH99
      Related
      FBpp0073133
      Conserved Domains (1) summary
      pfam00282
      Location:64 → 434
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PH99 M9PH99
    P20228.2 P20228

    Gene LinkOut

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