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    Sox14 Sox box protein 14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37822, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sox14provided by FlyBase
    Official Full Name
    Sox box protein 14provided by FlyBase
    Primary source
    FLYBASE:FBgn0005612
    Locus tag
    Dmel_CG3090
    See related
    AllianceGenome:FB:FBgn0005612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17263; CG3090; Dmel\CG3090; Dsox-14; DSox-14; DSox14; DSox60B; Sox-14; sox14; SOX14; SOX60B; SOXC
    Summary
    Enables DNA binding activity, bending and sequence-specific DNA binding activity. Involved in several processes, including neuron development; positive regulation of neuron remodeling; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; gut section; mesoderm; and salivary gland. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 10 and urinary bladder cancer. Orthologous to several human genes including SOX4 (SRY-box transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sox14 in Genome Data Viewer
    Location:
    60A16-60A16; 2-105 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23978801..23985177)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19866324..19872700)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene morula Neighboring gene Protein phosphatase 1 regulatory subunit 15 Neighboring gene Peptidylglycine-alpha-hydroxylating monooxygenase Neighboring gene uncharacterized protein Neighboring gene PAS kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of an SRY-like gene, DSox14, from Drosophila. Sparkes AC, et al. Gene, 2001 Jul 11. PMID 11470517
    2. A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning. Kirilly D, et al. Nat Neurosci, 2009 Dec. PMID 19881505, Free PMC Article
    3. PHM is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila. Jiang N, et al. Dev Biol, 2000 Oct 1. PMID 10993678
    4. Ancestry and diversity of the HMG box superfamily. Laudet V, et al. Nucleic Acids Res, 1993 May 25. PMID 8506143, Free PMC Article
    5. The BEAF-32 insulator coordinates genome organization and function during the evolution of Drosophila species. Yang J, et al. Genome Res, 2012 Nov. PMID 22895281, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sox14 is a critical transcription factor required for 20E signaling at the onset of metamorphosis.
      Title: Sox14 is required for transcriptional and developmental responses to 20-hydroxyecdysone at the onset of drosophila metamorphosis.
    2. a previously unknown pathway composed of Sox14 and its cytoskeletal target Mical governs dendrite severing during development
      Title: A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in metamorphosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron remodeling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sox box protein 14
    Names
    CG3090-PA
    CG3090-PB
    CG3090-PC
    Sox14-PA
    Sox14-PB
    Sox14-PC
    sox box protein 14

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23978801..23985177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299872.1 → NP_001286801.1  Sox box protein 14, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286801.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40656, Q2MGM9, Q9U1H4, Q9W1E2, Q9W1E3
      UniProtKB/TrEMBL
      A0A0B4LGC4
      Conserved Domains (1) summary
      cd01388
      Location:186 → 257
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

    2. NM_057546.3 → NP_476894.1  Sox box protein 14, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476894.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40656, Q2MGM9, Q9U1H4, Q9W1E2, Q9W1E3
      UniProtKB/TrEMBL
      A0A0B4LGC4
      Related
      FBpp0072066
      Conserved Domains (1) summary
      cd01388
      Location:186 → 257
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

    3. NM_134290.1 → NP_599117.1  Sox box protein 14, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599117.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40656, Q2MGM9, Q9U1H4, Q9W1E2, Q9W1E3
      UniProtKB/TrEMBL
      A0A0B4LGC4
      Related
      FBpp0072067, FBtr0072158
      Conserved Domains (1) summary
      cd01388
      Location:186 → 257
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGC4 A0A0B4LGC4
    P40656.3 P40656

    Gene LinkOut

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