E2f1 E2F transcription factor 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: E2f1provided by FlyBase
Official Full Name: E2F transcription factor 1provided by FlyBase
Primary source: FLYBASE:FBgn0011766
Locus tag: Dmel_CG6376
See related: AllianceGenome:FB:FBgn0011766
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6376; dE2f; dE2F; de2f1; dE2f1; dE2F1; def21; DmE2F-1; Dmel\CG6376; Dp; drosE2F1; DRTF1/E2F; E(Sev-CycE)3A; E(var)3-93E; E(var)3-95E; E(var)93E; e2f; E2f; E2F; E2F-1; e2f1; E2F1; Evar(3)164; l(3)07172; l(3)j3B1; l(3)j3C2; l(3)rM729
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including DNA endoreduplication; cellular response to gamma radiation; and regulation of gene expression. Located in nucleus. Part of Rb-E2F complex. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; gut section; head epidermis primordium; and nephrocyte. Used to study prostate cancer. Human ortholog(s) of this gene implicated in lung carcinoma (multiple); osteosarcoma; and pancreatic adenocarcinoma (multiple). Orthologous to several human genes including E2F1 (E2F transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 93E9-93F1; 3-72 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21620304..21660871, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17446026..17486593, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E2F1, DIAP1, and the presence of a homologous chromosome promote while JNK inhibits radiation-induced loss of heterozygosity in Drosophila melanogaster.
Title: E2F1, DIAP1, and the presence of a homologous chromosome promote while JNK inhibits radiation-induced loss of heterozygosity in Drosophila melanogaster.
Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells.
Title: Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells.
Normal cell cycle progression requires negative regulation of E2F1 by Groucho during S phase and its relief at G2 phase.
Title: Normal cell cycle progression requires negative regulation of E2F1 by Groucho during S phase and its relief at G2 phase.
E2F regulation of the Phosphoglycerate kinase gene is functionally important in Drosophila development.
Title: E2F regulation of the Phosphoglycerate kinase gene is functionally important in Drosophila development.
Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.
Title: Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.
Proper CycE-Cdk2 activity in endocycling tissues requires regulation of the cyclin-dependent kinase inhibitor Dacapo by dE2F1b in Drosophila.
Title: Proper CycE-Cdk2 activity in endocycling tissues requires regulation of the cyclin-dependent kinase inhibitor Dacapo by dE2F1b in Drosophila.
Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication.
Title: Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication.
dE2F1b is a novel member of the E2F family, revealing a previously unappreciated complexity in the Drosophila RB/E2F network.
Title: An alternatively spliced form affecting the Marked Box domain of Drosophila E2F1 is required for proper cell cycle regulation.
specific alternate transcripts of activator E2F, dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor
Title: Alternate transcripts of the Drosophila "activator" E2F are necessary for maintenance of cell cycle exit during development.
These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.
Title: E2F function in muscle growth is necessary and sufficient for viability in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fb33b12.x1 (e-PCR)
- UniSTS:190403

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
contributes_to sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA endoreduplication	IGI Inferred from Genetic Interaction more info	PubMed
involved_in DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G1/S transition of mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eggshell chorion gene amplification	TAS Traceable Author Statement more info	PubMed
involved_in larval lymph gland hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nurse cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in ventral cord development	HMP more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rb-E2F complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E2F transcription factor 1

Names: CG6376-PA; CG6376-PB; CG6376-PC; CG6376-PD; CG6376-PE; CG6376-PF; E2-promoter binding factor; E2F transcription factor; E2f1-PA; E2f1-PB; E2f1-PC; E2f1-PD; E2f1-PE; E2f1-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

21620304..21660871 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300526.1 → NP_001287455.1 E2F transcription factor 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287455.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O77035, Q27368, Q5U0Z6

UniProtKB/TrEMBL

A0A0B4LHG1

Conserved Domains (2) summary

cd14660
Location:327 → 428

E2F_DD; Dimerization domain of E2F transcription factors

pfam02319
Location:256 → 318

E2F_TDP; E2F/DP family winged-helix DNA-binding domain
NM_169962.3 → NP_732647.1 E2F transcription factor 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732647.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O77035, Q27368, Q5U0Z6

UniProtKB/TrEMBL

A0A0B4LHG1

Related

FBpp0083517

Conserved Domains (2) summary

cd14660
Location:327 → 428

E2F_DD; Dimerization domain of E2F transcription factors

pfam02319
Location:256 → 318

E2F_TDP; E2F/DP family winged-helix DNA-binding domain
NM_001300525.1 → NP_001287454.1 E2F transcription factor 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287454.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGM3

Conserved Domains (3) summary

cd14660
Location:327 → 362

E2F_DD; coiled coil [structural motif]

pfam02319
Location:256 → 318

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

cl22411
Location:327 → 444

E2F_DD; Dimerization domain of E2F transcription factors
NM_169961.3 → NP_732646.1 E2F transcription factor 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732646.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O77035, Q27368, Q5U0Z6

UniProtKB/TrEMBL

A0A0B4LHG1

Related

FBpp0083516

Conserved Domains (2) summary

cd14660
Location:327 → 428

E2F_DD; Dimerization domain of E2F transcription factors

pfam02319
Location:256 → 318

E2F_TDP; E2F/DP family winged-helix DNA-binding domain
NM_079713.3 → NP_524437.2 E2F transcription factor 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524437.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O77035, Q27368, Q5U0Z6

UniProtKB/TrEMBL

A0A0B4LHG1

Related

FBpp0083518

Conserved Domains (2) summary

cd14660
Location:327 → 428

E2F_DD; Dimerization domain of E2F transcription factors

pfam02319
Location:256 → 318

E2F_TDP; E2F/DP family winged-helix DNA-binding domain
NM_001275880.2 → NP_001262809.1 E2F transcription factor 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262809.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGM3

Conserved Domains (3) summary

cd14660
Location:327 → 362

E2F_DD; coiled coil [structural motif]

pfam02319
Location:256 → 318

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

cl22411
Location:327 → 444

E2F_DD; Dimerization domain of E2F transcription factors