caup caupolican [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: caupprovided by FlyBase
Official Full Name: caupolicanprovided by FlyBase
Primary source: FLYBASE:FBgn0015919
Locus tag: Dmel_CG10605
See related: AllianceGenome:FB:FBgn0015919
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Caup; CG10605; Dmel\CG10605; iro; Iro; iro-C; Iro-C; IRO-C; IroC
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including compound eye morphogenesis; imaginal disc-derived wing vein specification; and muscle cell fate commitment. Predicted to be active in nucleus. Is expressed in several structures, including cuboidal/columnar epithelium; germ layer; imaginal disc; segment; and transverse muscle cell. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to several human genes including IRX6 (iroquois homeobox 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 69D1-69D1; 3-38 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12609631..12621798)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12602731..12614898)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

complementary expression of omb and Iro-C establishes the wing hinge/notum fold formation
Title: Complementary expression of optomotor-blind and the Iroquois complex promotes fold formation to separate wing notum and hinge territories.
physical interaction of the Iroquois protein Caupolican with Cyclin E-containing protein complexes, through its IRO box and Cyclin-binding domains, underlies its activity in cell-cycle control.
Title: The Homeodomain Iroquois Proteins Control Cell Cycle Progression and Regulate the Size of Developmental Fields.
Data show that genes araucan and caupolican as novel muscle identity genes that confer lateral transverse muscle identity, and the acquisition of this fate requires that Araucan/Caupolican repress other muscle identity genes such as slouch and vestigial.
Title: Drosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate.
Caupolican and mirror, but not araucan, are required for the neural patterning of the lateral notum and are required for stripe expression and, therefore, to specify the muscular attachment sites prepattern.
Title: Prepatterning the Drosophila notum: the three genes of the iroquois complex play intrinsically distinct roles.
Antagonistic and cooperative actions of the EGFR and Dpp pathways on the iroquois genes regulate Drosophila mesothorax specification and patterning.
Title: Antagonistic and cooperative actions of the EGFR and Dpp pathways on the iroquois genes regulate Drosophila mesothorax specification and patterning.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in equator specification	TAS Traceable Author Statement more info	PubMed
involved_in imaginal disc-derived wing vein specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitotic cell cycle	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: caupolican

Names: CG10605-PA; caup-PA; cauplican; iroquis complex; iroquois; iroquois gene complex; iroquois-complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

12609631..12621798

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079322.3 → NP_524046.2 caupolican [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524046.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P54269, Q5BIH8, Q5U1A6, Q8MR03, Q9VU00

Related

FBpp0075641

Conserved Domains (2) summary

smart00548
Location:455 → 472

IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function

pfam05920
Location:244 → 283

Homeobox_KN; Homeobox KN domain