U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Alp4 Alkaline phosphatase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43671, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Alp4provided by FlyBase
    Official Full Name
    Alkaline phosphatase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0016123
    Locus tag
    Dmel_CG1462
    See related
    AllianceGenome:FB:FBgn0016123
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aph-4; Aph-4; CG1462; Dmel\CG1462; l(3)07028; pMY51
    Summary
    Predicted to enable alkaline phosphatase activity. Involved in epithelial fluid transport; nervous system development; and sexual reproduction. Predicted to be located in cell surface and extracellular space. Is expressed in several structures, including adult brain; adult ellipsoid body ring neurons; adult head; adult pars intercerebralis; and epithelial tube. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Alp4 in Genome Data Viewer
    Location:
    100B1-100B1; 3-102 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31048929..31052540)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26874651..26878262)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Calcineurin A1 Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene mir-4948 stem loop Neighboring gene Coiled-coil-helix-coiled-coil-helix domain containing 3 Neighboring gene discs overgrown

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Tissue-specific expression of a type I adenylyl cyclase rescues the rutabaga mutant memory defect: in search of the engram. Zars T, et al. Learn Mem, 2000 Jan. PMID 10706599, Free PMC Article
    2. Functional dissection of the Drosophila mushroom bodies by selective feminization of genetically defined subcompartments. O'Dell KM, et al. Neuron, 1995 Jul. PMID 7619530
    3. The Neuroanatomical Ultrastructure and Function of a Biological Ring Attractor. Turner-Evans DB, et al. Neuron, 2020 Oct 14. PMID 32916090, Free PMC Article
    4. Building the central complex in Drosophila: the generation and development of distinct neural subsets. Young JM, et al. J Comp Neurol, 2010 May 1. PMID 20187144
    5. Functional domains are specified to single-cell resolution in a Drosophila epithelium. Sözen MA, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144216, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkaline phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial fluid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    alkaline phosphatase 4
    Names
    Alp4-PA
    Alp4-PB
    CG1462-PA
    CG1462-PB
    alkaline phosphatase
    alkaline phosphatase-4
    NP_524601.2
    NP_733413.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31048929..31052540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079862.3 → NP_524601.2  alkaline phosphatase 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524601.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9EQR2, Q24238, Q3KN28, Q8IMH0, Q8SXW6, Q9VA19
      Related
      FBpp0085095
      Conserved Domains (2) summary
      smart00098
      Location:85 → 541
      alkPPc; Alkaline phosphatase homologues
      COG1785
      Location:60 → 534
      PhoA; Alkaline phosphatase [Inorganic ion transport and metabolism, General function prediction only]

    2. NM_170534.2 → NP_733413.1  alkaline phosphatase 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733413.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24238
      Related
      FBpp0085096
      Conserved Domains (1) summary
      smart00098
      Location:1 → 447
      alkPPc; Alkaline phosphatase homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24238.3 Q24238

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous