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    smid smallminded [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38824, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smidprovided by FlyBase
    Official Full Name
    smallmindedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016983
    Locus tag
    Dmel_CG8571
    See related
    AllianceGenome:FB:FBgn0016983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8571; Dmel\CG8571; l(3)j6B8; l(3)j8A6; l(3)s2898; Smid
    Summary
    Predicted to enable ATP hydrolysis activity and preribosome binding activity. Predicted to be involved in ribosome biogenesis. Predicted to be active in nucleus. Is expressed in several structures, including adult sense organ; hair plate; multidendritic neurons; organism subdivision; and visceral mesoderm derivative. Orthologous to human NVL (nuclear VCP like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See smid in Genome Data Viewer
    Location:
    65F9-65F10; 3-20 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7381614..7385637)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7374714..7378737)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene akirin Neighboring gene Sphingomyelin synthase related Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Central afferent projections of proprioceptive sensory neurons in Drosophila revealed with the enhancer-trap technique. Smith SA, et al. J Comp Neurol, 1996 Jan 8. PMID 8788252
    2. Isolation and characterisation of smallminded, a Drosophila gene encoding a new member of the Cdc48p/VCP subfamily of AAA proteins. Long AR, et al. Gene, 1998 Feb 27. PMID 9524263
    3. Persistent larval sensory neurons in adult Drosophila melanogaster. Williams DW, et al. J Neurobiol, 1999 May. PMID 10235681
    4. Tau and tau reporters disrupt central projections of sensory neurons in Drosophila. Williams DW, et al. J Comp Neurol, 2000 Dec 25. PMID 11077417
    5. Nociceptive neurons protect Drosophila larvae from parasitoid wasps. Hwang RY, et al. Curr Biol, 2007 Dec 18. PMID 18060782, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables preribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    smallminded
    Names
    CG8571-PA
    CG8571-PC
    CG8571-PG
    CG8571-PH
    CG8571-PI
    small-minded
    smid-PA
    smid-PC
    smid-PG
    smid-PH
    smid-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7381614..7385637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206287.3 → NP_996009.2  smallminded, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996009.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEP1, Q7KU82
      Conserved Domains (4) summary
      COG0464
      Location:237 → 885
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam00004
      Location:665 → 796
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam16725
      Location:1 → 37
      Nucleolin_bd; Nucleolin binding domain
      cl21455
      Location:645 → 682
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001274583.1 → NP_001261512.1  smallminded, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261512.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEP1, Q7KU82
      Conserved Domains (4) summary
      COG0464
      Location:237 → 885
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam00004
      Location:665 → 796
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam16725
      Location:1 → 37
      Nucleolin_bd; Nucleolin binding domain
      cl21455
      Location:645 → 682
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_079235.4 → NP_523959.2  smallminded, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523959.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VS62
      Related
      FBpp0089153
      Conserved Domains (4) summary
      COG0464
      Location:271 → 919
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam00004
      Location:699 → 830
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam16725
      Location:2 → 71
      Nucleolin_bd; Nucleolin binding domain
      cl21455
      Location:679 → 716
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_001169900.2 → NP_001163371.1  smallminded, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163371.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91638
      Conserved Domains (4) summary
      COG0464
      Location:270 → 918
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam00004
      Location:698 → 829
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam16725
      Location:2 → 71
      Nucleolin_bd; Nucleolin binding domain
      cl21455
      Location:678 → 715
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. NM_001274584.1 → NP_001261513.1  smallminded, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261513.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEE1
      Conserved Domains (4) summary
      COG0464
      Location:254 → 902
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam00004
      Location:682 → 813
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam16725
      Location:2 → 71
      Nucleolin_bd; Nucleolin binding domain
      cl21455
      Location:662 → 699
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEE1 M9PEE1
    P91638 P91638
    Q7KU82 Q7KU82
    Q8SXZ0 Q8SXZ0
    Q9VS62 Q9VS62

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