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    qm quemao [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    qmprovided by FlyBase
    Official Full Name
    quemaoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0019662
    Locus tag
    Dmel_CG8593
    See related
    AllianceGenome:FB:FBgn0019662
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bro2; CG8593; Dmel\CG8593; GGPPS; GGPPS/qm; Qm
    Summary
    Predicted to enable farnesyltranstransferase activity. Involved in embryonic heart tube development; germ cell migration; and oogenesis. Is expressed in several structures, including adult head; indirect flight muscle cell; larval visceral muscle cell; and visceral muscle primordium. Orthologous to human GGPS1 (geranylgeranyl diphosphate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    65F5-65F6; 3-20 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7348313..7353622)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7341413..7346722)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Signal recognition particle 19 Neighboring gene long non-coding RNA:CR45833 Neighboring gene CTCF Neighboring gene antisense RNA:CR45822 Neighboring gene pastrel

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A homologue of the 19 kDa signal recognition particle protein locus in Drosophila melanogaster. Lai C, et al. Gene, 1997 Dec 5. PMID 9426007
    2. quemao, a Drosophila bristle locus, encodes geranylgeranyl pyrophosphate synthase. Lai C, et al. Genetics, 1998 Jun. PMID 9611212, Free PMC Article
    3. The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. Yi P, et al. Science, 2006 Sep 1. PMID 16857902
    4. Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila. Gerasimova TI, et al. Mol Cell, 2007 Dec 14. PMID 18082602, Free PMC Article
    5. Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. Deshpande G, et al. PLoS Genet, 2009 Jan. PMID 19132091, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables farnesyltranstransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables farnesyltranstransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in isoprenoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    quemao
    Names
    CG8593-PA
    CG8593-PB
    CG8593-PC
    geranylgeranyl pyrophosphate synthase
    qm-PA
    qm-PB
    qm-PC
    que mao
    NP_001163370.1
    NP_001261510.1
    NP_523958.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7348313..7353622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169899.2 → NP_001163370.1  quemao, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163370.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61539, Q9VS54
      Conserved Domains (1) summary
      pfam00348
      Location:30 → 267
      polyprenyl_synt; Polyprenyl synthetase

    2. NM_079234.4 → NP_523958.2  quemao, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523958.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61539, Q9VS54
      Related
      FBpp0076557
      Conserved Domains (1) summary
      pfam00348
      Location:30 → 267
      polyprenyl_synt; Polyprenyl synthetase

    3. NM_001274581.1 → NP_001261510.1  quemao, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261510.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEL3, O61539
      Conserved Domains (1) summary
      pfam00348
      Location:30 → 255
      polyprenyl_synt; Polyprenyl synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEL3 M9PEL3
    O61538 O61538
    O61539 O61539
    Q5G1W2 Q5G1W2
    Q9VS54 Q9VS54

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