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    Cht10 Chitinase 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355116, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cht10provided by FlyBase
    Official Full Name
    Chitinase 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0250907
    Locus tag
    Dmel_CG18140
    See related
    AllianceGenome:FB:FBgn0250907
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LP04696; CG17682; CG18140; CG18140-PA3; Cht; cht1; Cht1; CHT1; cht10; cht3; Cht3; CHT3; DmCht1; DmCHT1; DmCht10; DmCHT10; DmCht3; DmCHT3; Dmel\CG18140
    Summary
    Predicted to enable chitin binding activity and chitinase activity. Predicted to be involved in chitin catabolic process. Predicted to be active in extracellular region. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; gut section; and primary segmental tracheal branch primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Cht10 in Genome Data Viewer
    Location:
    40F7-40F7; 2-54 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22999574..23025915, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22892306..22918647, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene concertina Neighboring gene long non-coding RNA:CR43242 Neighboring gene Spf45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chitinases are a multi-gene family in Aedes, Anopheles and Drosophila. de la Vega H, et al. Insect Mol Biol, 1998 Aug. PMID 9662472
    2. Evidence for the adaptive significance of an LTR retrotransposon sequence in a Drosophila heterochromatic gene. McCollum AM, et al. BMC Evol Biol, 2002 Mar 19. PMID 11914129, Free PMC Article
    3. Epigenomic and genomic landscape of Drosophila melanogaster heterochromatic genes. Saha P, et al. Genomics, 2019 Mar. PMID 29432976
    4. Chitinase 10 controls chitin amounts and organization in the wing cuticle of Drosophila. Dong W, et al. Insect Sci, 2020 Dec. PMID 32129536
    5. Characterization of recombinant chitinase-like proteins of Drosophila melanogaster and Tribolium castaneum. Zhu Q, et al. Insect Biochem Mol Biol, 2008 Apr. PMID 18342251

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chitinase 10 controls chitin amounts and organization in the wing cuticle of Drosophila.
      Title: Chitinase 10 controls chitin amounts and organization in the wing cuticle of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chitinase 10
    Names
    CG18140-PA
    CG18140-PB
    CG18140-PC
    Cht10-PA
    Cht10-PB
    Cht10-PC
    chitinase
    chitinase 1
    chitinase 3
    chitinase-1
    chitinase-3
    NP_001036422.1
    NP_001260697.1
    NP_001260698.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      22999574..23025915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042957.2 → NP_001036422.1  chitinase 10, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036422.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17420, O17422, Q7PL80, Q8MS85, Q9W5U2, Q9W5U3
      UniProtKB/TrEMBL
      M9PGH3
      Conserved Domains (4) summary
      cd02872
      Location:221 → 586
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00494
      Location:697 → 737
      ChtBD2; Chitin-binding domain type 2
      smart00636
      Location:1410 → 1753
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:875 → 918
      CBM_14; Chitin binding Peritrophin-A domain

    2. NM_001273769.1 → NP_001260698.1  chitinase 10, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260698.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17420, O17422, Q7PL80, Q8MS85, Q9W5U2, Q9W5U3
      UniProtKB/TrEMBL
      M9PGH3
      Conserved Domains (4) summary
      cd02872
      Location:221 → 586
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00494
      Location:697 → 737
      ChtBD2; Chitin-binding domain type 2
      smart00636
      Location:1410 → 1753
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:875 → 918
      CBM_14; Chitin binding Peritrophin-A domain

    3. NM_001273768.1 → NP_001260697.1  chitinase 10, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260697.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17420, O17422, Q7PL80, Q8MS85, Q9W5U2, Q9W5U3
      UniProtKB/TrEMBL
      M9PGH3
      Conserved Domains (4) summary
      cd02872
      Location:221 → 586
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00494
      Location:697 → 737
      ChtBD2; Chitin-binding domain type 2
      smart00636
      Location:1410 → 1753
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:875 → 918
      CBM_14; Chitin binding Peritrophin-A domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGH3 M9PGH3
    Q9W5U2.2 Q9W5U2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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