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    Tsp2A Tetraspanin 2A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31080, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp2Aprovided by FlyBase
    Official Full Name
    Tetraspanin 2Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024361
    Locus tag
    Dmel_CG11415
    See related
    AllianceGenome:FB:FBgn0024361
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11415; D8.7; Dm.Tsp2A; Dmel\CG11415; EG:8D8.7; tsp2a; tsp2A; Tsp2a
    Summary
    Involved in establishment of endothelial barrier; glial cell migration; and smooth septate junction assembly. Located in apicolateral plasma membrane and smooth septate junction. Is expressed in several structures, including embryonic/larval hemocyte; epithelium; ganglia; gut section; and somatic precursor cell. Human ortholog(s) of this gene implicated in retinitis pigmentosa 7. Orthologous to human ROM1 (retinal outer segment membrane protein 1); TSPAN10 (tetraspanin 10); and TSPAN32 (tetraspanin 32). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp2A in Genome Data Viewer
    Location:
    1F4-1F4; 1-0.1 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1346553..1348143)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1240586..1242176)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene N(alpha)-acetyltransferase 30 A Neighboring gene mitochondrial poly(A) polymerase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Septate junctions regulate gut homeostasis through regulation of stem cell proliferation and enterocyte behavior in Drosophila. Izumi Y, et al. J Cell Sci, 2019 Sep 26. PMID 31444286
    2. The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules in Drosophila melanogaster. Beyenbach KW, et al. Am J Physiol Cell Physiol, 2020 Jun 1. PMID 32267718, Free PMC Article
    3. Gut tumors in flies alter the taste valence of an anti-tumorigenic bitter compound. Leung NY, et al. Curr Biol, 2024 Jun 17. PMID 38823383,
    4. The novel membrane protein Hoka regulates septate junction organization and stem cell homeostasis in the Drosophila gut. Izumi Y, et al. J Cell Sci, 2021 Mar 26. PMID 33589496
    5. A tetraspanin regulates septate junction formation in Drosophila midgut. Izumi Y, et al. J Cell Sci, 2016 Mar 15. PMID 26848177

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules in Drosophila melanogaster.
      Title: The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules in Drosophila melanogaster.
    2. Together with Tsp2A, Ssk and Mesh form a protein complex, and all three proteins are required for smooth septate junctions (sSJs) formation, as well as intestinal barrier function.
      Title: Molecular dissection of smooth septate junctions: understanding their roles in arthropod physiology.
    3. Tsp2A regulates septate junction formation in Drosophila midgut.
      Title: A tetraspanin regulates septate junction formation in Drosophila midgut.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of endothelial barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glial cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in smooth septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in smooth septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetraspanin 2A
    Names
    CG11415-PA
    CG11415-PB
    Tsp2A-PA
    Tsp2A-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1346553..1348143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080298.4 → NP_525037.1  tetraspanin 2A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525037.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46101
      Related
      FBpp0070204
      Conserved Domains (2) summary
      cd03127
      Location:116 → 204
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:18 → 232
      Tetraspannin; Tetraspanin family

    2. NM_001201594.2 → NP_001188523.1  tetraspanin 2A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188523.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46101
      Conserved Domains (2) summary
      cd03127
      Location:116 → 204
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:18 → 232
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46101.1 O46101

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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