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    Rilpl Rab interacting lysosomal protein like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31090, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rilplprovided by FlyBase
    Official Full Name
    Rab interacting lysosomal protein likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024985
    Locus tag
    Dmel_CG11448
    See related
    AllianceGenome:FB:FBgn0024985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11448; Dmel\CG11448; EG:132E8.4; RILP
    Summary
    Enables GTP-dependent protein binding activity. Involved in lysosome localization. Located in lysosomal membrane and perinuclear region of cytoplasm. Is expressed in embryonic brain; larval nervous system; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in oculopharyngodistal myopathy 4. Orthologous to human RILPL1 (Rab interacting lysosomal protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rilpl in Genome Data Viewer
    Location:
    2A1-2A1; 1-0.2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1393054..1397337)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1287087..1291370)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene AMP-activated protein kinase alpha subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene futsch Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutional insights into the interaction between Rab7 and RILP in lysosome motility. Cui G, et al. iScience, 2023 Jul 21. PMID 37534141, Free PMC Article
    2. HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury. Krzystek TJ, et al. Autophagy, 2023 Apr. PMID 36048753, Free PMC Article
    3. The small G protein Arl8 contributes to lysosomal function and long-range axonal transport in Drosophila. Rosa-Ferreira C, et al. Biol Open, 2018 Sep 5. PMID 30115618, Free PMC Article
    4. Rab2 drives axonal transport of dense core vesicles and lysosomal organelles. Lund VK, et al. Cell Rep, 2021 Apr 13. PMID 33852866
    5. A transcriptional network associated with natural variation in Drosophila aggressive behavior. Edwards AC, et al. Genome Biol, 2009. PMID 19607677, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysosome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rab interacting lysosomal protein like
    Names
    CG11448-PA
    CG11448-PB
    CG11448-PC
    Rilpl-PA
    Rilpl-PB
    Rilpl-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1393054..1397337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272203.1 → NP_001259132.1  Rab interacting lysosomal protein like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259132.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG81
      Conserved Domains (3) summary
      pfam09744
      Location:26 → 186
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam11315
      Location:239 → 315
      Med30; Mediator complex subunit 30
      pfam14662
      Location:114 → 314
      KASH_CCD; Coiled-coil region of CCDC155 or KASH

    2. NM_130554.3 → NP_569910.1  Rab interacting lysosomal protein like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569910.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76878
      Related
      FBpp0070216
      Conserved Domains (3) summary
      pfam09744
      Location:26 → 186
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam11315
      Location:239 → 315
      Med30; Mediator complex subunit 30
      pfam14662
      Location:114 → 314
      KASH_CCD; Coiled-coil region of CCDC155 or KASH

    3. NM_001272204.1 → NP_001259133.1  Rab interacting lysosomal protein like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259133.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGM0
      Conserved Domains (3) summary
      pfam09744
      Location:26 → 186
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam11315
      Location:239 → 315
      Med30; Mediator complex subunit 30
      pfam14662
      Location:114 → 314
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PG81 M9PG81
    M9PGM0 M9PGM0
    O76878.1 O76878

    Gene LinkOut

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