amos absent MD neurons and olfactory sensilla [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: amosprovided by FlyBase
Official Full Name: absent MD neurons and olfactory sensillaprovided by FlyBase
Primary source: FLYBASE:FBgn0003270
Locus tag: Dmel_CG10393
See related: AllianceGenome:FB:FBgn0003270
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Amos; asolo; bHLHa10; CG10393; Dmel\CG10393; Roi; rolo; Tft
Summary: Enables protein heterodimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in dendrite morphogenesis and sensory organ precursor cell fate determination. Predicted to be active in nucleus. Is expressed in several structures, including adult antennal olfactory receptor neurons; antennal disc; female germline cell; segment; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and persistent hyperplastic primary vitreous. Orthologous to several human genes including ATOH1 (atonal bHLH transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (18596136..18596921, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (18596136..18596921, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

genetic ablation of Atonal Olfactory receptor neurons (ORNs) affects antennal lobe structure and axon targeting of Amos ORNs.
Title: Hierarchical axon targeting of Drosophila olfactory receptor neurons specified by the proneural transcription factors Atonal and Amos.
Despite their high similarity, much of Amos's specificity relative to Ato maps to Amos-specific residues in its basic helix-loop-helix domain.
Title: Functional distinctness of closely related transcription factors: a comparison of the Atonal and Amos proneural factors.
Rough eye is an allele of amos that disrupts regulation of the proneural gene atonal during Drosophila retinal differentiation.
Title: Rough eye is a gain-of-function allele of amos that disrupts regulation of the proneural gene atonal during Drosophila retinal differentiation.
Results show that amos is required to specify the precursors of two classes of olfactory sensilla.
Title: The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ boundary specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell fate determination	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

Names: CG10393-PA; Rough-eye; absent MD neurons; amos; amos-PA; rough eye; tufted

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The following sections contain reference sequences that belong to a specific genome build. Explain