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    CG4701 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34858, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4701provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028868
    Locus tag
    Dmel_CG4701
    See related
    AllianceGenome:FB:FBgn0028868
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS06874.3; DmDM19DC4Z; Dmel\CG4701
    Summary
    Predicted to enable membrane protein dislocase activity. Predicted to be involved in extraction of mislocalized protein from mitochondrial outer membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hyperekplexia 4. Orthologous to human ATAD1 (ATPase family AAA domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4701 in Genome Data Viewer
    Location:
    35B5-35B5; 2-50 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14765908..14767225)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14765908..14767225)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44858 Neighboring gene COP9 signalosome subunit 1a Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An AAA family tree. Fröhlich KU. J Cell Sci, 2001 May. PMID 11309190
    2. Burst of young retrogenes and independent retrogene formation in mammals. Pan D, et al. PLoS One, 2009. PMID 19325906, Free PMC Article
    3. Comparative genomics reveals a constant rate of origination and convergent acquisition of functional retrogenes in Drosophila. Bai Y, et al. Genome Biol, 2007. PMID 17233920, Free PMC Article
    4. Parent genes of retrotransposition-generated gene duplicates in Drosophila melanogaster have distinct expression profiles. Langille MG, et al. Genomics, 2007 Sep. PMID 17628393
    5. Nuclear chromosome dynamics in the Drosophila male germ line contribute to the nonrandom genomic distribution of retrogenes. Díaz-Castillo C, et al. Mol Biol Evol, 2012 Sep. PMID 22427708

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables membrane protein dislocase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in extraction of mislocalized protein from mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extraction of mislocalized protein from mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4701-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14765908..14767225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135877.3 → NP_609721.1  uncharacterized protein Dmel_CG4701 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609721.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZ76, Q9V3Q1
      Related
      FBpp0080234
      Conserved Domains (3) summary
      smart00382
      Location:130 → 265
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:133 → 265
      AAA; ATPase family associated with various cellular activities (AAA)
      cl24009
      Location:47 → 152
      Parvo_NS1; Parvovirus non-structural protein NS1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MZ76 Q8MZ76
    Q9V3Q1 Q9V3Q1

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