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    AdamTS-B ADAM metallopeptidase with thrombospondin type 1 motif B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31490, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AdamTS-Bprovided by FlyBase
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029791
    Locus tag
    Dmel_CG4096
    See related
    AllianceGenome:FB:FBgn0029791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4096; CT13580; Dmel\CG4096
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and negative regulation of imaginal disc-derived wing vein specification. Predicted to be active in extracellular matrix. Is expressed in several structures, including clypeo-labral primordium; dorsal epidermis primordium; embryonic epipharynx; embryonic hypopharynx; and presumptive wing vein. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome and congenital heart disease. Orthologous to several human genes including ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12) and ADAMTS7 (ADAM metallopeptidase with thrombospondin type 1 motif 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AdamTS-B in Genome Data Viewer
    Location:
    5B1-5B1; 1-13 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5698557..5708633)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5592590..5602666)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42794 Neighboring gene uncharacterized protein Neighboring gene crossveinless Neighboring gene uncharacterized protein Neighboring gene Sorting nexin 27 Neighboring gene uncharacterized protein Neighboring gene Integrator 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The extracellular protease AdamTS-B inhibits vein formation in the Drosophila wing. Pham MN, et al. Genesis, 2018 Dec. PMID 30296002
    2. Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization. Nicholson AC, et al. BMC Evol Biol, 2005 Feb 4. PMID 15693998, Free PMC Article
    3. Sol narae (Sona) is a Drosophila ADAMTS involved in Wg signaling. Kim GW, et al. Sci Rep, 2016 Aug 18. PMID 27535473, Free PMC Article
    4. The secreted AdamTS-A metalloprotease is required for collective cell migration. Ismat A, et al. Development, 2013 May. PMID 23536567, Free PMC Article
    5. Molecular evolution of the Yap/Yorkie proto-oncogene and elucidation of its core transcriptional program. Ikmi A, et al. Mol Biol Evol, 2014 Jun. PMID 24509725, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADAM metallopeptidase with thrombospondin type 1 motif B
    Names
    AdamTS-B-PB
    AdamTS-B-PC
    CG4096-PB
    CG4096-PC
    NP_001162678.1
    NP_572247.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5698557..5708633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132019.3 → NP_572247.2  ADAM metallopeptidase with thrombospondin type 1 motif B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572247.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W493
      Conserved Domains (6) summary
      smart00209
      Location:614 → 666
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:314 → 518
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:315 → 521
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:78 → 194
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:773 → 886
      ADAM_spacer1; ADAM-TS Spacer 1
      cl15456
      Location:558 → 602
      ADAM_CR; ADAM cysteine-rich

    2. NM_001169207.1 → NP_001162678.1  ADAM metallopeptidase with thrombospondin type 1 motif B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162678.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRL5
      Conserved Domains (5) summary
      smart00209
      Location:614 → 666
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:314 → 518
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:315 → 521
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:78 → 194
      Pep_M12B_propep; Reprolysin family propeptide
      cl15456
      Location:558 → 602
      ADAM_CR; ADAM cysteine-rich
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRL5 Q8MRL5
    Q9W493 Q9W493

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