Grip Glutamate receptor interacting protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gripprovided by FlyBase
Official Full Name: Glutamate receptor interacting proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0029830
Locus tag: Dmel_CG14447
See related: AllianceGenome:FB:FBgn0029830
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14447; CG5980; dgrip; dGRIP; Dgrip; DGrip; Dmel\CG14447; grip; GRIP
Summary: Enables signaling receptor binding activity. Involved in determination of muscle attachment site; muscle organ morphogenesis; and synapse organization. Located in Golgi-associated vesicle; neuromuscular junction; and terminal bouton. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; larval muscle cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in Fraser syndrome 3. Orthologous to several human genes including GRIP2 (glutamate receptor interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 5D1-5D1; 1-15 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5966279..5986699)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5860312..5880732)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

propose that Perd regulates projection of myotube processes the myotendinous junction by priming formation of a protein complex through its intracellular interaction with Grip and the tendon cell-expressed laminin-binding alpha PS1-beta PS integrin
Title: The transmembrane protein Perdido interacts with Grip and integrins to mediate myotube projection and attachment in the Drosophila embryo.
Kon is enriched at myotube tips during targeting and signals through the intracellular adaptor Dgrip in a conserved molecular pathway.
Title: The transmembrane protein Kon-tiki couples to Dgrip to mediate myotube targeting in Drosophila.
We propose that Ed and DGrip form a signaling complex, where competition between N-terminal and the C-terminal PDZDs of DGrip for Ed binding controls signaling function
Title: Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesis.
Data show that GRIP is necessary for the trafficking of Frizzled-2 to the nucleus.
Title: Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in determination of muscle attachment site	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle attachment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi-associated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutamate receptor interacting protein

Names: CG14447-PA; CG14447-PB; CG14447-PC; Glutamate-receptor-interacting-protein; Grip-PA; Grip-PB; Grip-PC; glutamate receptor binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

5966279..5986699

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_132057.3 → NP_572285.2 glutamate receptor interacting protein, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572285.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8SY14, Q9W449, Q9W450

Related

FBpp0070830

Conserved Domains (2) summary

cd00992
Location:832 → 913

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl00117
Location:496 → 521

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
NM_001297991.1 → NP_001284920.1 glutamate receptor interacting protein, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284920.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SY14, X2JIJ6

Conserved Domains (2) summary

cd00992
Location:831 → 912

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl00117
Location:495 → 520

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
NM_001297992.1 → NP_001284921.1 glutamate receptor interacting protein, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284921.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SY14, X2JIJ6

Conserved Domains (2) summary

cd00992
Location:831 → 912

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl00117
Location:495 → 520

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...