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    spri sprint [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spriprovided by FlyBase
    Official Full Name
    sprintprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085443
    Locus tag
    Dmel_CG34414
    See related
    AllianceGenome:FB:FBgn0085443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.275; CG12638; CG15297; CG15298; CG15299; CG15300; CG15301; CG32674; CG32680; CG33175; CG34414; Dmel\CG34414; Rin1; Spri
    Old locus tag
    CG32680; CG33175; Dmel_CG32680; Dmel_CG33175
    Summary
    Enables receptor tyrosine kinase binding activity and small GTPase binding activity. Involved in axon extension; positive regulation of border follicle cell migration; and positive regulation of receptor-mediated endocytosis. Located in cell cortex and endocytic vesicle. Is expressed in several structures, including amnioserosa; embryonic/larval midgut primordium; gland; imaginal disc; and nephrocyte. Orthologous to several human genes including RIN2 (Ras and Rab interactor 2) and RIN3 (Ras and Rab interactor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spri in Genome Data Viewer
    Location:
    9D2-9D3; 1-32 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10490069..10585422, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10384102..10479455, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Protein phosphatase 4 regulatory subunit 2-related protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rab at 9D Neighboring gene Hybrid male rescue

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Second-order moments of segregating sites under variable population size. Zivković D, et al. Genetics, 2008 Sep. PMID 18716326, Free PMC Article
    2. Cloning and expression of sprint, a Drosophila homologue of RIN1. Szabó K, et al. Mech Dev, 2001 Mar. PMID 11231087
    3. Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons. Carney DS, et al. Trends Cell Biol, 2006 Jan. PMID 16330212
    4. The molecular signature of BCR::ABL(P210) and BCR::ABL(T315I) in a Drosophila melanogaster chronic myeloid leukemia model. Baassiri A, et al. iScience, 2024 Apr 19. PMID 38585663, Free PMC Article
    5. RasGAP mediates neuronal survival in Drosophila through direct regulation of Rab5-dependent endocytosis. Rowshanravan B, et al. J Cell Sci, 2014 Jul 1. PMID 24816559

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of border follicle cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Rab protein signal transduction ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sprint
    Names
    CG34414-PA
    CG34414-PE
    CG34414-PF
    CG34414-PG
    CG34414-PI
    CG34414-PJ
    CG34414-PL
    CG34414-PM
    CG34414-PN
    CG34414-PO
    CG34414-PP
    CG34414-PQ
    CG34414-PR
    spri-PA
    spri-PE
    spri-PF
    spri-PG
    spri-PI
    spri-PJ
    spri-PL
    spri-PM
    spri-PN
    spri-PO
    spri-PP
    spri-PQ
    spri-PR
    sprint-a
    sprint-b

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10490069..10585422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272491.1 → NP_001259420.1  sprint, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (2) summary
      pfam02204
      Location:415 → 516
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:540 → 620
      UBQ; Ubiquitin-like proteins

    2. NM_001272490.1 → NP_001259419.1  sprint, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259419.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (2) summary
      pfam02204
      Location:221 → 322
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:346 → 426
      UBQ; Ubiquitin-like proteins

    3. NM_001103474.2 → NP_001096944.1  sprint, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096944.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (2) summary
      pfam02204
      Location:499 → 600
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:624 → 704
      UBQ; Ubiquitin-like proteins

    4. NM_001272487.1 → NP_001259416.1  sprint, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259416.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PE83, M9PGU3, M9PH67, M9PHI9, M9PJH2, M9PJH3, Q3KN60, Q8MQV9, Q8MQW8, Q8T4E9, Q9BK48, Q9BK49, Q9W2T4, Q9W2T7, Q9W2U1, T2GGG1
      Conserved Domains (3) summary
      cd01776
      Location:1692 → 1776
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      pfam02204
      Location:1570 → 1668
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:462 → 559
      SH2; Src homology 2 (SH2) domain

    5. NM_001272486.1 → NP_001259415.1  sprint, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259415.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PE83, M9PGU3, M9PH67, M9PHI9, M9PJH2, M9PJH3, Q3KN60, Q8MQV9, Q8MQW8, Q8T4E9, Q9BK48, Q9BK49, Q9W2T4, Q9W2T7, Q9W2U1, T2GGG1
      Conserved Domains (3) summary
      cd01776
      Location:1692 → 1776
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      pfam02204
      Location:1570 → 1668
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:462 → 559
      SH2; Src homology 2 (SH2) domain

    6. NM_001272492.1 → NP_001259421.1  sprint, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259421.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (3) summary
      pfam02204
      Location:1319 → 1420
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:1444 → 1524
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:214 → 311
      SH2; Src homology 2 (SH2) domain

    7. NM_001272488.1 → NP_001259417.1  sprint, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259417.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (3) summary
      pfam02204
      Location:1319 → 1420
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:1444 → 1524
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:214 → 311
      SH2; Src homology 2 (SH2) domain

    8. NM_001103471.2 → NP_001096941.2  sprint, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096941.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (3) summary
      pfam02204
      Location:1227 → 1328
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:1352 → 1432
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:122 → 219
      SH2; Src homology 2 (SH2) domain

    9. NM_001272485.1 → NP_001259414.1  sprint, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259414.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (3) summary
      pfam02204
      Location:1554 → 1655
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:1679 → 1759
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:449 → 546
      SH2; Src homology 2 (SH2) domain

    10. NM_206678.2 → NP_996401.1  sprint, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996401.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PE83, M9PGU3, M9PH67, M9PHI9, M9PJH2, M9PJH3, Q3KN60, Q8MQV9, Q8MQW8, Q8T4E9, Q9BK48, Q9BK49, Q9W2T4, Q9W2T7, Q9W2U1, T2GGG1
      Conserved Domains (3) summary
      cd01776
      Location:1692 → 1776
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      pfam02204
      Location:1570 → 1668
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:462 → 559
      SH2; Src homology 2 (SH2) domain

    11. NM_001272489.1 → NP_001259418.1  sprint, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259418.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (3) summary
      pfam02204
      Location:1821 → 1922
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:1946 → 2026
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:716 → 813
      SH2; Src homology 2 (SH2) domain

    12. NM_001272484.1 → NP_001259413.1  sprint, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259413.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (3) summary
      pfam02204
      Location:1554 → 1655
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:1679 → 1759
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:449 → 546
      SH2; Src homology 2 (SH2) domain

    13. NM_176723.3 → NP_788896.1  sprint, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788896.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Related
      FBpp0111601
      Conserved Domains (3) summary
      pfam02204
      Location:1554 → 1655
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:1679 → 1759
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:449 → 546
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MQW8.3 Q8MQW8

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