e(y)2 enhancer of yellow 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: e(y)2provided by FlyBase
Official Full Name: enhancer of yellow 2provided by FlyBase
Primary source: FLYBASE:FBgn0000618
Locus tag: Dmel_CG15191
See related: AllianceGenome:FB:FBgn0000618
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15191; de(y)2; dE(y)2; dENY2; Dmel\CG15191; E(y)2; e(y)[2]; e(y2); ENY2; LBC; Sus1
Summary: Enables C2H2 zinc finger domain binding activity; TFIID-class transcription factor complex binding activity; and chromatin insulator sequence binding activity. Involved in heterochromatin boundary formation; poly(A)+ mRNA export from nucleus; and positive regulation of transcription by RNA polymerase II. Located in chromatin and nuclear periphery. Part of SAGA complex and nucleus. Orthologous to human ENY2 (ENY2 transcription and export complex 2 subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 10C7-10C7; 1-35 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (11576118..11576620, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (11470151..11470653, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ENY2 Protein Interacts with RNA Helicase MLE
Title: Multifunctional ENY2 Protein Interacts with RNA Helicase MLE.
Evolutionarily conserved ENY2 is responsible for barrier activity mediated by the dCTCF protein.
Title: Highly conserved ENY2/Sus1 protein binds to Drosophila CTCF and is required for barrier activity.
The transcription coactivators SAYP and ENY2 act in gene expression as cooperative nanoregulators,determining the molecular mechanisms of spatial and temporal coordination of the processes involved in the realization of genetic information.
Title: [Functioning of macromolecular complexes at successive stages of gene expression as self-coordinated molecular machines].
ENY2 protein forms a part of the THO complex of Drosophila melanogaster.
Title: ENY2 protein forms a part of the THO complex of Drosophila melanogaster.
368-bp core of E(y)2 insulator is sufficient for blocking Polycomb response element-mediated silencing.
Title: E(y)2/Sus1 is required for blocking PRE silencing by the Wari insulator in Drosophila melanogaster.
ENY2 in Drosophila is also stably associated with THO, the complex involved in mRNP biogenesis
Title: Multifunctional factor ENY2 is associated with the THO complex and promotes its recruitment onto nascent mRNA.
E(y)2 and Xmas-2 together with SAGA/TFTC functioned in the anchoring of a subset of transcription sites to the NPCs to achieve efficient transcription and mRNA export.
Title: [Conservative E(y)2/Sus1 protein is the member of SAGA complex and new nuclear pore-associated complex in Drosophila].
E(y)2, the novel component of SAGA/TFTC complex in eucaryotes participates in export of mRNP from nucleus and couples transcription with nuclear pore
Title: [E(y)2, the novel component of SAGA/TFTC complex in eucaryotes participates in export of mRNP from nucleus and couples transcription with nuclear pore].
transcription factor E(y)2/Sus1 interacted with the Su(Hw) zinc-finger domain and was present in the protein complex, associated with the Su(Hw)-dependent insulators.
Title: [Conservative E(y)2/Sus1 protein interacts with the Su(Hw)-dependent insulators in Drosophila].
3 additional subunits of TFTC/STAGA (ATXN7L3, USP22, & ENY2) help form the deubiquitination module. This module is an enhancer of position effect variegation in Drosophila. ATXN7L3 and USP22.
Title: A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables C2H2 zinc finger domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables TFIID-class transcription factor complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin insulator sequence binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heterochromatin boundary formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in poly(A)+ mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of DUBm complex	IBA Inferred from Biological aspect of Ancestor more info
part_of DUBm complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	IEA Inferred from Electronic Annotation more info
part_of SAGA complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription export complex 2	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: enhancer of yellow 2

Names: CG15191-PA; e(y)2-PA; late boundary complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

11576118..11576620 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080107.3 → NP_524846.1 enhancer of yellow 2 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524846.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VYX1

UniProtKB/TrEMBL

A0A1B2AIW8

Related

FBpp0073385

Conserved Domains (1) summary

pfam10163
Location:6 → 87

EnY2; Transcription factor e(y)2