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    mmd mind-meld [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32561, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mmdprovided by FlyBase
    Official Full Name
    mind-meldprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259110
    Locus tag
    Dmel_CG42252
    See related
    AllianceGenome:FB:FBgn0259110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15603; CG15604; CG42252; CG9163; CT26192; Dmel\CG42252
    Old locus tag
    Dmel_CG15603; Dmel_CG15604; Dmel_CG9163
    Summary
    Predicted to be located in membrane. Is expressed in adult head; dorsal head epidermis; embryonic brain; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Orthologous to several human genes including ADAM22 (ADAM metallopeptidase domain 22) and ADAM23 (ADAM metallopeptidase domain 23). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mmd in Genome Data Viewer
    Location:
    14A1-14A4; 1-52 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15946936..15973159, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15840969..15867192, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ribosomal RNA processing 47 Neighboring gene mir-927 stem loop Neighboring gene long non-coding RNA:CR45527 Neighboring gene Odorant receptor 13a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome. Sanfilippo P, et al. Neuron, 2024 Mar 20. PMID 38262414,
    2. Drosophila metalloproteases in development and differentiation: the role of ADAM proteins and their relatives. Meyer H, et al. Eur J Cell Biol, 2011 Sep. PMID 21684629
    3. Drosophila in asthma research. Roeder T, et al. Am J Respir Crit Care Med, 2009 Jun 1. PMID 19342413
    4. The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning. Hull R, et al. Int J Mol Sci, 2015 May 6. PMID 25955646, Free PMC Article
    5. Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Mukherjee C, et al. Cell Metab, 2020 Aug 4. PMID 32531201, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mind-meld
    Names
    CG42252-PB
    CG42252-PD
    CG42252-PE
    CG42252-PF
    CG42252-PG
    CG42252-PH
    CG42252-PI
    CG42252-PJ
    Meltrin-like
    Mind-meld
    mind meld
    mmd-PB
    mmd-PD
    mmd-PE
    mmd-PF
    mmd-PG
    mmd-PH
    mmd-PI
    mmd-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15946936..15973159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258776.2 → NP_001245705.1  mind-meld, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245705.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDY9
      Conserved Domains (5) summary
      smart00608
      Location:566 → 713
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:270 → 471
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:488 → 562
      Disintegrin; Disintegrin
      pfam01421
      Location:270 → 473
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:106 → 213
      Pep_M12B_propep; Reprolysin family propeptide

    2. NM_001272662.2 → NP_001259591.1  mind-meld, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259591.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PH86
      Conserved Domains (5) summary
      smart00608
      Location:566 → 713
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:270 → 471
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:488 → 562
      Disintegrin; Disintegrin
      pfam01421
      Location:270 → 473
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:106 → 213
      Pep_M12B_propep; Reprolysin family propeptide

    3. NM_001272661.2 → NP_001259590.1  mind-meld, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259590.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PER2
      Conserved Domains (5) summary
      smart00608
      Location:566 → 713
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:270 → 471
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:488 → 562
      Disintegrin; Disintegrin
      pfam01421
      Location:270 → 473
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:106 → 213
      Pep_M12B_propep; Reprolysin family propeptide

    4. NM_078634.7 → NP_523358.5  mind-meld, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523358.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXL1
      Conserved Domains (5) summary
      smart00608
      Location:566 → 713
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:270 → 471
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:488 → 562
      Disintegrin; Disintegrin
      pfam01421
      Location:270 → 473
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:106 → 213
      Pep_M12B_propep; Reprolysin family propeptide

    5. NM_001298382.1 → NP_001285311.1  mind-meld, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285311.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JE21
      Conserved Domains (5) summary
      smart00608
      Location:566 → 713
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:270 → 471
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:488 → 562
      Disintegrin; Disintegrin
      pfam01421
      Location:270 → 473
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:106 → 213
      Pep_M12B_propep; Reprolysin family propeptide

    6. NM_001144728.3 → NP_001138200.1  mind-meld, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0Y2
      Conserved Domains (5) summary
      smart00608
      Location:566 → 713
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:270 → 471
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:488 → 562
      Disintegrin; Disintegrin
      pfam01421
      Location:270 → 473
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:106 → 213
      Pep_M12B_propep; Reprolysin family propeptide

    7. NM_001258775.3 → NP_001245704.1  mind-meld, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245704.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NH46
      Conserved Domains (5) summary
      smart00608
      Location:566 → 713
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:270 → 471
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:488 → 562
      Disintegrin; Disintegrin
      pfam01421
      Location:270 → 473
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:106 → 213
      Pep_M12B_propep; Reprolysin family propeptide

    8. NM_206752.3 → NP_996475.2  mind-meld, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996475.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUY7, Q9GZ15
      Conserved Domains (5) summary
      smart00608
      Location:566 → 713
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:270 → 471
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:488 → 562
      Disintegrin; Disintegrin
      pfam01421
      Location:270 → 473
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:106 → 213
      Pep_M12B_propep; Reprolysin family propeptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0Y2 B7Z0Y2
    M9NDY9 M9NDY9
    M9NH46 M9NH46
    M9PER2 M9PER2
    M9PH86 M9PH86
    Q7KUY7 Q7KUY7
    Q9GZ15 Q9GZ15
    Q9VXL1 Q9VXL1
    X2JE21 X2JE21

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