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    ppk28 pickpocket 28 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32671, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppk28provided by FlyBase
    Official Full Name
    pickpocket 28provided by FlyBase
    Primary source
    FLYBASE:FBgn0030795
    Locus tag
    Dmel_CG4805
    See related
    AllianceGenome:FB:FBgn0030795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4805; Dmel\CG4805; ppk-28; PPK-28; Ppk28; PPK28
    Summary
    Predicted to enable ligand-gated sodium channel activity. Involved in cellular response to water stimulus; drinking behavior; and liquid clearance, open tracheal system. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in eo-type sensillum; gustatory receptor neurons; primary tracheal branch; and tracheal tip cell. Orthologous to several human genes including ASIC1 (acid sensing ion channel subunit 1); ASIC2 (acid sensing ion channel subunit 2); and ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppk28 in Genome Data Viewer
    Location:
    15A9-15A10; 1-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16806068..16808515)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16700101..16702548)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44053 Neighboring gene Rat1 Interacting Protein 1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44129 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster as an organism model for studying cystic fibrosis and its major associated microbial infections. Touré H, et al. Infect Immun, 2023 Nov 16. PMID 37847031, Free PMC Article
    2. Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling. Waterson MJ, et al. Proc Natl Acad Sci U S A, 2014 Jun 3. PMID 24821805, Free PMC Article
    3. The molecular basis for water taste in Drosophila. Cameron P, et al. Nature, 2010 May 6. PMID 20364123, Free PMC Article
    4. Drosophila gustatory projections are segregated by taste modality and connectivity. Engert S, et al. Elife, 2022 May 25. PMID 35611959, Free PMC Article
    5. Long-range projection neurons in the taste circuit of Drosophila. Kim H, et al. Elife, 2017 Feb 6. PMID 28164781, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results confirm a role for ppk28 in promoting water consumption in drosophila.
      Title: A simple high throughput assay to evaluate water consumption in the fruit fly.
    2. We found that loss of the critical water sensor, pickpocket 28 (ppk28), altered metabolic homeostasis to promote internal lipid and water stores and extended healthy lifespan.
      Title: Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling.
    3. the amiloride-sensitive PPK28 channel may serve as the osmolarity sensor for gustatory water reception in the fruit fly.
      Title: The amiloride-sensitive epithelial Na+ channel PPK28 is essential for drosophila gustatory water reception.
    4. a member of the degenerin/epithelial sodium channel family, PPK28, as an osmosensitive ion channel that mediates the cellular and behavioural response to water
      Title: The molecular basis for water taste in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to water stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in drinking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in liquid clearance, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to water IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pickpocket 28
    Names
    CG4805-PA
    ppk28-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16806068..16808515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132941.3 → NP_573169.2  pickpocket 28 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573169.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86LG0, Q86LG1, Q9VXA6
      Conserved Domains (1) summary
      pfam00858
      Location:43 → 509
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86LG1.2 Q86LG1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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