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    shv shriveled [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33220, updated on 9-Dec-2024

    Summary

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    Official Symbol
    shvprovided by FlyBase
    Official Full Name
    shriveledprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031256
    Locus tag
    Dmel_CG4164
    See related
    AllianceGenome:FB:FBgn0031256
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4164; Dmel\CG4164
    Summary
    Enables integrin binding activity. Involved in several processes, including germ-line stem-cell niche homeostasis; male germ-line stem cell population maintenance; and positive regulation of integrin-mediated signaling pathway. Located in extracellular space and neuromuscular junction. Is expressed in several structures, including adult head; circulatory system primordium; ganglia; male germline cell; and somatic cell of testis. Human ortholog(s) of this gene implicated in polycystic kidney disease 6. Orthologous to human DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See shv in Genome Data Viewer
    Location:
    21C2-21C2; 2-0.7 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (453108..454654)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (453108..454654)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene expanded Neighboring gene long non-coding RNA:CR43717 Neighboring gene croquemort Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at the Drosophila Neuromuscular Junction. Lee JY, et al. J Neurosci, 2017 Mar 22. PMID 28219985, Free PMC Article
    2. Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling. Lee JY, et al. PLoS Genet, 2016 May. PMID 27191715, Free PMC Article
    3. Identification of secretory autophagy as a mechanism modulating activity-induced synaptic remodeling. Chang YC, et al. Proc Natl Acad Sci U S A, 2024 Apr 16. PMID 38588427, Free PMC Article
    4. Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila. Desai M, et al. PLoS Biol, 2024 Apr. PMID 38648719, Free PMC Article
    5. Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy. Uytterhoeven V, et al. Neuron, 2015 Nov 18. PMID 26590345

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in germ-line stem-cell niche homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    shriveled
    Names
    CG4164-PA
    shv-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      453108..454654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134681.3 → NP_608525.1  shriveled [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608525.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VPQ2
      Related
      FBpp0077720
      Conserved Domains (4) summary
      cd10747
      Location:131 → 328
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:22 → 346
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:25 → 87
      DnaJ; DnaJ domain
      cl21539
      Location:160 → 195
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPQ2.1 Q9VPQ2

    Gene LinkOut

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