U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Prosbeta4R1 Proteasome beta4 subunit-related 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33449, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Prosbeta4R1provided by FlyBase
    Official Full Name
    Proteasome beta4 subunit-related 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031442
    Locus tag
    Dmel_CG17301
    See related
    AllianceGenome:FB:FBgn0031442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT30033; beta4R1; CG17301; Dmel\CG17301
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Orthologous to human PSMB2 (proteasome 20S subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Prosbeta4R1 in Genome Data Viewer
    Location:
    23A2-23A2; 2-7 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2653046..2653926)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2653046..2653926)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome beta4 subunit-related 2 Neighboring gene Odorant receptor 23a Neighboring gene TBP-related factor 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Proteasome Structure and Assembly. Budenholzer L, et al. J Mol Biol, 2017 Nov 10. PMID 28583440, Free PMC Article
    2. Population genomic inferences from sparse high-throughput sequencing of two populations of Drosophila melanogaster. Sackton TB, et al. Genome Biol Evol, 2009 Nov 18. PMID 20333214, Free PMC Article
    3. Expression of proteasome subunit isoforms during spermatogenesis in Drosophila melanogaster. Ma J, et al. Insect Mol Biol, 2002 Dec. PMID 12421421
    4. Lethality in Drosophila melanogaster/Drosophila simulans species hybrids is not associated with substantial transcriptional misregulation. Barbash DA, et al. J Exp Zool B Mol Dev Evol, 2007 Jan 15. PMID 17075830
    5. Duplicated proteasome subunit genes in Drosophila and their roles in spermatogenesis. Belote JM, et al. Heredity (Edinb), 2009 Jul. PMID 19277057

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    NOT enables peptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasomal protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    proteasome beta4 subunit-related 1
    Names
    CG17301-PA
    Prosbeta4R1-PA
    proteasome beta4R1 subunit

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2653046..2653926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134854.3 → NP_608698.2  proteasome beta4 subunit-related 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608698.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8U1, Q9VQE4
      Related
      FBpp0077381
      Conserved Domains (2) summary
      COG0638
      Location:1 → 204
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03758
      Location:1 → 193
      proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T8U1 Q8T8U1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools