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    Tmtc1 Transmembrane O-mannosyltransferase targeting cadherins 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmtc1provided by FlyBase
    Official Full Name
    Transmembrane O-mannosyltransferase targeting cadherins 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0051690
    Locus tag
    Dmel_CG31690
    See related
    AllianceGenome:FB:FBgn0051690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11542; CG15397; CG31690; Dmel\CG31690; TMTC1
    Summary
    Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human TMTC2 (transmembrane O-mannosyltransferase targeting cadherins 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tmtc1 in Genome Data Viewer
    Location:
    23A2-23A2; 2-7 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2677734..2719431)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2677734..2719431)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Gustatory receptor 23a Neighboring gene TBP-related factor 5 Neighboring gene uncharacterized protein Neighboring gene mir-4914 stem loop Neighboring gene Hepatocyte growth factor regulated tyrosine kinase substrate Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites. Eisenhaber B, et al. Biol Direct, 2021 Jan 12. PMID 33436046, Free PMC Article
    2. Protein O-mannosylation: one sugar, several pathways, many functions. Koff M, et al. Glycobiology, 2023 Dec 25. PMID 37565810, Free PMC Article
    3. Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression. Ghavi-Helm Y, et al. Nat Genet, 2019 Aug. PMID 31308546, Free PMC Article
    4. Identification of Genes Contributing to a Long Circadian Period in Drosophila Melanogaster. Kumar S, et al. J Biol Rhythms, 2021 Jun. PMID 33274675, Free PMC Article
    5. RNA degradation is required for the germ-cell to maternal transition in Drosophila. Blatt P, et al. Curr Biol, 2021 Jul 26. PMID 33989522, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked mannosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane O-mannosyltransferase targeting cadherins 1
    Names
    CG31690-PE
    Tmtc1-PE
    NP_995615.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2677734..2719431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_205893.3 → NP_995615.2  transmembrane O-mannosyltransferase targeting cadherins 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995615.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3PFE4, Q7KU17, Q8T3V2, Q9VQE9
      UniProtKB/TrEMBL
      T2GG64
      Conserved Domains (6) summary
      smart00028
      Location:808 → 841
      TPR; Tetratricopeptide repeats
      COG0457
      Location:565 → 841
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:518 → 546
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:552 → 584
      TPR_1; Tetratricopeptide repeat
      pfam08409
      Location:272 → 340
      DUF1736; Domain of unknown function (DUF1736)
      pfam13414
      Location:518 → 583
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQE9.3 Q9VQE9

    Gene LinkOut

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