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    Cwc25 Cwc25 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33460, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cwc25provided by FlyBase
    Official Full Name
    Cwc25provided by FlyBase
    Primary source
    FLYBASE:FBgn0031452
    Locus tag
    Dmel_CG2843
    See related
    AllianceGenome:FB:FBgn0031452
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2843; CWC25; Dmel\CG2843
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U2-type spliceosomal complex. Orthologous to human CWC25 (CWC25 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cwc25 in Genome Data Viewer
    Location:
    23A3-23A3; 2-7 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2745098..2746944)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2745098..2746944)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-4914 stem loop Neighboring gene Hepatocyte growth factor regulated tyrosine kinase substrate Neighboring gene uncharacterized protein Neighboring gene Phosphoglycerate kinase Neighboring gene Bacchus Neighboring gene long non-coding RNA:CR44772 Neighboring gene SNAP associated protein Neighboring gene HemK methyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function. Wang P, et al. J Neurosci, 2004 May 12. PMID 15140922, Free PMC Article
    2. Multi-level and lineage-specific interactomes of the Hox transcription factor Ubx contribute to its functional specificity. Carnesecchi J, et al. Nat Commun, 2020 Mar 13. PMID 32170121, Free PMC Article
    3. Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity. Butzlaff M, et al. Hum Mol Genet, 2015 Jul 1. PMID 25794683
    4. A Drosophila protein-interaction map centered on cell-cycle regulators. Stanyon CA, et al. Genome Biol, 2004. PMID 15575970, Free PMC Article
    5. Proteomic Analysis of the Ubiquitin Landscape in the Drosophila Embryonic Nervous System and the Adult Photoreceptor Cells. Ramirez J, et al. PLoS One, 2015. PMID 26460970, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cwc25
    Names
    CG2843-PA
    Cwc25-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2745098..2746944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134861.2 → NP_608705.1  Cwc25 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608705.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQF5
      Related
      FBpp0077396
      Conserved Domains (2) summary
      pfam10197
      Location:11 → 44
      Cir_N; N-terminal domain of CBF1 interacting co-repressor CIR
      pfam12542
      Location:72 → 174
      CWC25; Pre-mRNA splicing factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQF5 Q9VQF5

    Gene LinkOut

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