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    COX5BL Cytochrome c oxidase subunit 5B-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33919, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX5BLprovided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 5B-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031831
    Locus tag
    Dmel_CG11043
    See related
    AllianceGenome:FB:FBgn0031831
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11043; COXB; Dmel\CG11043; Vb
    Summary
    Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial envelope. Is expressed in adult head and spermatozoon. Orthologous to human COX5B (cytochrome c oxidase subunit 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See COX5BL in Genome Data Viewer
    Location:
    26E3-26E3; 2-21 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6559431..6560133)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6559431..6560133)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Intraflagellar transport 52 Neighboring gene Cytochrome c oxidase subunit 5B Neighboring gene tRNA methyltransferase 6 non-catalytic subunit Neighboring gene uncharacterized protein Neighboring gene Equilibrative nucleoside transporter 2 Neighboring gene Dipeptidyl peptidase 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan. Klichko V, et al. Biochem J, 2014 Apr 1. PMID 24444354
    2. Variation in Mitochondria-Derived Transcript Levels Associated With DDT Resistance in the 91-R Strain of Drosophila melanogaster (Diptera: Drosophilidae). Steele LD, et al. J Insect Sci, 2018 Nov 1. PMID 30383265, Free PMC Article
    3. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Szuplewski S, et al. Genetics, 2001 Aug. PMID 11514451, Free PMC Article
    4. Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. Doggett K, et al. Dev Biol, 2011 Jul 15. PMID 21570388, Free PMC Article
    5. Two functionally different mitochondrial phosphate carriers support Drosophila melanogaster OXPHOS throughout distinct developmental stages. Curcio R, et al. Biochim Biophys Acta Mol Cell Res, 2024 Jan. PMID 37898376

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 5B-like
    Names
    CG11043-PA
    COX5BL-PA
    cytochrome c oxidase polypeptide Vb

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6559431..6560133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135203.3 → NP_609047.1  cytochrome c oxidase subunit 5B-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609047.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMB8
      Related
      FBpp0078919
      Conserved Domains (1) summary
      cd00924
      Location:63 → 154
      Cyt_c_Oxidase_Vb; Cytochrome c oxidase subunit Vb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMB8 Q9VMB8

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