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    Proc Proctolin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 250710, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Procprovided by FlyBase
    Official Full Name
    Proctolinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0045038
    Locus tag
    Dmel_CG7105
    See related
    AllianceGenome:FB:FBgn0045038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7105; Dmel\CG7105; Prct; proc; PROC; proct; Proct; PROCT
    Summary
    Enables neuropeptide hormone activity and proctolin receptor binding activity. Involved in locomotion; neuropeptide signaling pathway; and positive regulation of heart rate. Predicted to be located in extracellular space. Is expressed in several structures, including brain; embryonic central brain neurons; embryonic/larval corpus cardiacum; larval neuromere; and larval neurons. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Proc in Genome Data Viewer
    Location:
    28D2-28D2; 2-29 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7864642..7871432, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7864642..7871432, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene lectin-28C Neighboring gene TweedleE Neighboring gene transfer RNA:Glycine-GCC 1-3 Neighboring gene long non-coding RNA:CR45364

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the neuropeptide transmitter proctolin in Drosophila larvae: characterization of muscle fiber-specific neuromuscular endings. Anderson MS, et al. J Neurosci, 1988 Jan. PMID 2892897, Free PMC Article
    2. Chemical analysis of neurotransmitter candidates in clonal cell lines from Drosophila central nervous system, II: Neuropeptides and amino acids. Ui-Tei K, et al. Neurosci Lett, 1995 Aug 11. PMID 8584206
    3. Characterization of a functionally expressed dipeptidyl aminopeptidase III from Drosophila melanogaster. Mazzocco C, et al. Eur J Biochem, 2003 Jul. PMID 12846841
    4. Nox regulation of smooth muscle contraction. Ritsick DR, et al. Free Radic Biol Med, 2007 Jul 1. PMID 17561091, Free PMC Article
    5. Tissue-specific cell sorting from Drosophila embryos: application to gene expression analysis. Salmand PA, et al. Fly (Austin), 2011 Jul-Sep. PMID 21654211

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proctolin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proctolin
    Names
    CG7105-PA
    CG7105-PB
    Proc-PA
    Proc-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7864642..7871432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135314.3 → NP_609158.2  proctolin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609158.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLV9
      Related
      FBpp0079184

    2. NM_001298799.1 → NP_001285728.1  proctolin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285728.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLV9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLV9 Q9VLV9

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