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    spz3 spatzle 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34077, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spz3provided by FlyBase
    Official Full Name
    spatzle 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0031959
    Locus tag
    Dmel_CG7104
    See related
    AllianceGenome:FB:FBgn0031959
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14533; CG7104; CT21967; CT34263; Dmel\CG7104; Spz-3; Spz3
    Summary
    Predicted to enable Toll binding activity and growth factor activity. Predicted to be involved in central nervous system formation and innate immune response. Located in extracellular space. Is expressed in adult heart; dorsal pharyngeal muscle cell; larval muscle system; larval somatic muscle cell; and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spz3 in Genome Data Viewer
    Location:
    28D2-28D2; 2-29 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7873495..7879552, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7873495..7879552, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45364 Neighboring gene transfer RNA:Glycine-GCC 1-3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Small ribonucleoprotein particle protein SmE

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantifying Glial-Glial Tiling Using Automated Image Analysis in Drosophila. Salazar G, et al. Front Cell Neurosci, 2022. PMID 35401121, Free PMC Article
    2. Retrograde neurotrophin signaling through Tollo regulates synaptic growth in Drosophila. Ballard SL, et al. J Cell Biol, 2014 Mar 31. PMID 24662564, Free PMC Article
    3. Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells. Seong KH, et al. Commun Biol, 2020 May 4. PMID 32367035, Free PMC Article
    4. Evolutionary and functional epitopes of the Spätzle protein: new insights into activation of the Toll receptor. Wang Y, et al. Cell Mol Life Sci, 2009 May. PMID 19308321, Free PMC Article
    5. A family of proteins related to Spätzle, the toll receptor ligand, are encoded in the Drosophila genome. Parker JS, et al. Proteins, 2001 Oct 1. PMID 11536362

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spz3 is a novel signaling factor required for maintenance of cortex glial morphology and neuron-glia contact.
      Title: The secreted neurotrophin Spätzle 3 promotes glial morphogenesis and supports neuronal survival and function.
    2. Spz3 expression in muscle and proteolytic activation via the Easter protease is necessary and sufficient to promote NMJ growth.
      Title: Retrograde neurotrophin signaling through Tollo regulates synaptic growth in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Toll binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spatzle 3
    Names
    CG7104-PA
    Spz3
    spatzle3
    spz3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7873495..7879552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135316.3 → NP_609160.2  spatzle 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609160.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8WTE9, Q9VLV7
      Related
      FBpp0079183
      Conserved Domains (1) summary
      pfam16077
      Location:520 → 607
      Spaetzle; Spaetzle
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLV7.2 Q9VLV7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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