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    Spn28Dc Serpin 28Dc [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34091, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spn28Dcprovided by FlyBase
    Official Full Name
    Serpin 28Dcprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031973
    Locus tag
    Dmel_CG7219
    See related
    AllianceGenome:FB:FBgn0031973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7219; Dm-Spn28D; Dmel\CG7219; spn28D; Spn28D
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in negative regulation of melanization defense response; negative regulation of proteolysis; and response to wounding. Located in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including angioedema (multiple); artery disease (multiple); chronic obstructive pulmonary disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to several human genes including SERPINA12 (serpin family A member 12) and SERPINF2 (serpin family F member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spn28Dc in Genome Data Viewer
    Location:
    28D3-28D3; 2-29 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8004548..8007210, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8004548..8007210, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44996 Neighboring gene uncharacterized protein Neighboring gene Starvation-upregulated protein Neighboring gene WW domain containing oxidoreductase Neighboring gene uncharacterized protein Neighboring gene Glycine N-acyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Resolving the phylogenetic relationships and evolutionary history of the Drosophila virilis group using multilocus data. Morales-Hojas R, et al. Mol Phylogenet Evol, 2011 Aug. PMID 21571080
    2. A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade. Colinet D, et al. Dev Comp Immunol, 2009 May. PMID 19109990
    3. Comparative analysis of five immunity-related genes reveals different levels of adaptive evolution in the virilis and melanogaster groups of Drosophila. Morales-Hojas R, et al. Heredity (Edinb), 2009 Jun. PMID 19223926
    4. Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation. Scherfer C, et al. Dev Biol, 2008 Nov 15. PMID 18801354
    5. Spatial regulation of developmental signaling by a serpin. Hashimoto C, et al. Dev Cell, 2003 Dec. PMID 14667416

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serpin 28Dc
    Names
    CG7219-PA
    Dm-serpin-28D
    Serpin-28D
    Serpin28Dc
    Spn28Dc-PA
    serpin 28D

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8004548..8007210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135328.3 → NP_609172.1  serpin 28Dc [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609172.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VLU4
      UniProtKB/TrEMBL
      A4V9T5
      Related
      FBpp0079171
      Conserved Domains (1) summary
      cd00172
      Location:111 → 527
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLU4.2 Q9VLU4

    Gene LinkOut

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