PICK1 Protein interacting with C kinase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PICK1provided by FlyBase
Official Full Name: Protein interacting with C kinase 1provided by FlyBase
Primary source: FLYBASE:FBgn0032447
Locus tag: Dmel_CG6167
See related: AllianceGenome:FB:FBgn0032447
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6167; Dmel\CG6167; dPICK1
Summary: Predicted to enable membrane curvature sensor activity; phospholipid binding activity; and protein kinase C binding activity. Involved in several processes, including cellular response to sucrose stimulus; positive regulation of developmental growth; and regulation of postsynapse organization. Located in neuronal cell body. Is expressed in several structures, including adult antennal lobe; adult brain; adult head; cell body rind region; and ganglia. Orthologous to human PICK1 (protein interacting with PRKCA 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 33F3-33F3; 2-47 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (12695033..12698917)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (12695033..12698917)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutational disruption of the helix in PICK1 impaired membrane curvature sensing without affecting membrane binding per se.
Title: An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1.
study found that the PICK1 protein is widely expressed in neuroendocrine cells in the Drosophila CNS
Title: PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables membrane curvature sensor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	ISM Inferred from Sequence Model more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to sucrose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in dendritic spine maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulated exocytosis	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic early endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein interacting with C kinase 1

Names: CG6167-PA; CG6167-PB; CG6167-PD; CG6167-PE; CG6167-PF; PICK1 ortholog; PICK1-PA; PICK1-PB; PICK1-PD; PICK1-PE; PICK1-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

12695033..12698917

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298952.1 → NP_001285881.1 protein interacting with C kinase 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285881.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JDZ1

Conserved Domains (2) summary

cd07659
Location:221 → 436

BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1

cd00992
Location:98 → 174

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_135738.3 → NP_609582.3 protein interacting with C kinase 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609582.3

Status: REVIEWED

UniProtKB/TrEMBL

Q8SY07, Q9VK66

Related

FBpp0079976

Conserved Domains (2) summary

cd07659
Location:148 → 363

BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1

cd00992
Location:25 → 101

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_165018.2 → NP_723766.1 protein interacting with C kinase 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723766.1

Status: REVIEWED

UniProtKB/TrEMBL

M9ND78, Q86PF5

Related

FBpp0079977

Conserved Domains (2) summary

cd07659
Location:131 → 346

BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1

cd00992
Location:8 → 84

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001259080.2 → NP_001246009.2 protein interacting with C kinase 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246009.2

Status: REVIEWED

UniProtKB/TrEMBL

M9ND78, Q86PF5

Conserved Domains (2) summary

cd07659
Location:131 → 346

BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1

cd00992
Location:8 → 84

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001298951.1 → NP_001285880.1 protein interacting with C kinase 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285880.1

Status: REVIEWED

UniProtKB/TrEMBL

M9ND78, Q86PF5

Conserved Domains (2) summary

cd07659
Location:131 → 346

BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1

cd00992
Location:8 → 84

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...