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    btv beethoven [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35073, updated on 9-Dec-2024

    Summary

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    Official Symbol
    btvprovided by FlyBase
    Official Full Name
    beethovenprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023096
    Locus tag
    Dmel_CG15148
    See related
    AllianceGenome:FB:FBgn0023096
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15148; DHC; DHC2; Dhc36D; DHC36D; Dmel\CG15148
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in several processes, including adult walking behavior; intraciliary retrograde transport; and male courtship behavior, veined wing generated song production. Located in axoneme. Is expressed in chordotonal organ precursor cell; external sensory organ precursor cell; and spermatozoon. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy and asphyxiating thoracic dystrophy 3. Orthologous to human DYNC2H1 (dynein cytoplasmic 2 heavy chain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See btv in Genome Data Viewer
    Location:
    36E3-36E3; 2-53 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17962625..17982472, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17962625..17982472, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44399 Neighboring gene long non-coding RNA:CR44398 Neighboring gene long non-coding RNA:CR44397 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome beta5 subunit-related 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Mismatch EndoNuclease Array-Based Methodology (MENA) for Identifying Known SNPs or Novel Point Mutations. Comeron JM, et al. Microarrays (Basel), 2016 Apr 5. PMID 27600073, Free PMC Article
    2. Power gain exhibited by motile mechanosensory neurons in Drosophila ears. Göpfert MC, et al. Proc Natl Acad Sci U S A, 2005 Jan 11. PMID 15623551, Free PMC Article
    3. Song production in auditory mutants of Drosophila: the role of sensory feedback. Tauber E, et al. J Comp Physiol A, 2001 Jun. PMID 11529478
    4. More whistles and bells for fly hearing. Walker RG. Proc Natl Acad Sci U S A, 2003 May 13. PMID 12732710, Free PMC Article
    5. Motion generation by Drosophila mechanosensory neurons. Göpfert MC, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12642657, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in auditory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary retrograde transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary retrograde transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior, veined wing generated song production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beethoven
    Names
    CG15148-PD
    DyneinHC
    btv-PD
    dynein heavy chain 36D

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17962625..17982472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042904.4 → NP_001036369.3  beethoven [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036369.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8P6
      Conserved Domains (6) summary
      pfam03028
      Location:3536 → 4051
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:200 → 618
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1072 → 1481
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2821 → 3138
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3179 → 3401
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1621 → 1847
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8P6 Q0E8P6

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