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    Pde11 Phosphodiesterase 11 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35107, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pde11provided by FlyBase
    Official Full Name
    Phosphodiesterase 11provided by FlyBase
    Primary source
    FLYBASE:FBgn0085370
    Locus tag
    Dmel_CG34341
    See related
    AllianceGenome:FB:FBgn0085370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10231; CG15159; CG34341; Dmel\CG34341; pde11; PDE11
    Old locus tag
    CG10231; CG15159; Dmel_CG10231; Dmel_CG15159
    Summary
    Enables 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cAMP metabolic process and cGMP metabolic process. Located in cytosol. Is expressed in several structures, including Malpighian tubule primordium; adult brain cell body rind; adult gnathal ganglion; embryonic/larval midgut primordium; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human PDE5A (phosphodiesterase 5A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pde11 in Genome Data Viewer
    Location:
    36F6-36F6; 2-53 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18532025..18590342, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18532025..18590342, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase family 301 member D1 Neighboring gene long non-coding RNA:CR44903 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene absent MD neurons and olfactory sensilla

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NMDA Receptor-mediated Ca2+ Influx in the Absence of Mg2+ Block Disrupts Rest: Activity Rhythms in Drosophila. Song Q, et al. Sleep, 2017 Dec 1. PMID 29029290
    2. Cyclic nucleotide phosphodiesterases in Drosophila melanogaster. Day JP, et al. Biochem J, 2005 May 15. PMID 15673286, Free PMC Article
    3. White - cGMP Interaction Promotes Fast Locomotor Recovery from Anoxia in Adult Drosophila. Xiao C, et al. PLoS One, 2017. PMID 28060942, Free PMC Article
    4. The transmembrane protein Kon-tiki couples to Dgrip to mediate myotube targeting in Drosophila. Schnorrer F, et al. Dev Cell, 2007 May. PMID 17488626
    5. Cell signalling mechanisms for insect stress tolerance. Davies SA, et al. J Exp Biol, 2014 Jan 1. PMID 24353211

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    phosphodiesterase 11
    Names
    CG34341-PB
    CG34341-PC
    CG34341-PD
    CG34341-PE
    CG34341-PF
    CG34341-PG
    Pde11-PB
    Pde11-PC
    Pde11-PD
    Pde11-PE
    Pde11-PF
    Pde11-PG
    NP_001097177.1
    NP_001188837.1
    NP_001188838.1
    NP_001286044.1
    NP_001286045.1
    NP_609885.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18532025..18590342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201909.2 → NP_001188838.1  phosphodiesterase 11, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188838.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRK1
      Conserved Domains (2) summary
      smart00065
      Location:376 → 538
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:815 → 1050
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. NM_001299115.1 → NP_001286044.1  phosphodiesterase 11, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286044.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW0, Q9VJ78, Q9VJ79
      UniProtKB/TrEMBL
      X2J6P6
      Conserved Domains (2) summary
      smart00065
      Location:420 → 582
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:859 → 1094
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. NM_001299116.1 → NP_001286045.1  phosphodiesterase 11, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286045.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J8Z1
      Conserved Domains (2) summary
      smart00065
      Location:376 → 538
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:815 → 1050
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. NM_001103707.2 → NP_001097177.1  phosphodiesterase 11, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J8Z1
      Conserved Domains (2) summary
      smart00065
      Location:376 → 538
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:815 → 1050
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. NM_001201908.2 → NP_001188837.1  phosphodiesterase 11, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188837.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSJ0
      Conserved Domains (2) summary
      smart00065
      Location:420 → 582
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:859 → 1094
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    6. NM_136041.2 → NP_609885.2  phosphodiesterase 11, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609885.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW0, Q9VJ78, Q9VJ79
      UniProtKB/TrEMBL
      X2J6P6
      Conserved Domains (2) summary
      smart00065
      Location:420 → 582
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:859 → 1094
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRK1 M9MRK1
    M9MSJ0 M9MSJ0
    Q9VJ79.4 Q9VJ79
    X2J6P6 X2J6P6
    X2J8Z1 X2J8Z1

    Gene LinkOut

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