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    Rab9 Rab9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35221, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rab9provided by FlyBase
    Official Full Name
    Rab9provided by FlyBase
    Primary source
    FLYBASE:FBgn0032782
    Locus tag
    Dmel_CG9994
    See related
    AllianceGenome:FB:FBgn0032782
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    146494_at; CG9994; Dmel\CG9994; DmRab9; rab9
    Summary
    Predicted to enable GTPase activity. Involved in retrograde transport, endosome to Golgi. Located in early endosome; late endosome; and trans-Golgi network. Is expressed in several structures, including Bolwig organ; brain; embryonic/larval tracheal section; glial cell; and imaginal disc. Orthologous to human RAB9A (RAB9A, member RAS oncogene family) and RAB9B (RAB9B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rab9 in Genome Data Viewer
    Location:
    37E1-37E1; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19432574..19435841)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19432574..19435841)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Paxillin Neighboring gene uncharacterized protein Neighboring gene Alkaline phosphatase 12 Neighboring gene RtcB RNA ligase Neighboring gene uncharacterized protein Neighboring gene Ran GTPase activating protein Neighboring gene Heparan sulfate 2-O-sulfotransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control. Dong B, et al. Nat Commun, 2013. PMID 23322046, Free PMC Article
    2. A fat body-derived apical extracellular matrix enzyme is transported to the tracheal lumen and is required for tube morphogenesis in Drosophila. Dong B, et al. Development, 2014 Nov. PMID 25336738, Free PMC Article
    3. Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning. Dodson MW, et al. Hum Mol Genet, 2012 Mar 15. PMID 22171073, Free PMC Article
    4. Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila. Inoshita T, et al. Hum Mol Genet, 2017 Aug 1. PMID 28482024
    5. Endocytosis at the Drosophila blood-brain barrier as a function for sleep. Artiushin G, et al. Elife, 2018 Nov 26. PMID 30475209, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome HDA PubMed 
    located_in synapse HDA PubMed 
    located_in synaptic vesicle HDA PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Rab9
    Names
    CG9994-PA
    Rab9-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19432574..19435841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136122.4 → NP_609966.1  Rab9 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609966.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIW6
      Related
      FBpp0080747
      Conserved Domains (2) summary
      cd04116
      Location:8 → 178
      Rab9; Rab GTPase family 9 (Rab9)
      pfam00071
      Location:14 → 177
      Ras; Ras family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIW6 Q9VIW6

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