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    Eaf ELL-associated factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35660, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eafprovided by FlyBase
    Official Full Name
    ELL-associated factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033166
    Locus tag
    Dmel_CG11166
    See related
    AllianceGenome:FB:FBgn0033166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11166; CG1706; dEaf; Dmel\CG11166; EP(2)2475; LD35207
    Summary
    Predicted to enable transcription elongation factor activity. Involved in cellular response to heat and positive regulation of DNA-templated transcription. Located in nucleoplasm. Part of super elongation complex. Is expressed in adult brain cell body rind and organism. Orthologous to human EAF1 (ELL associated factor 1) and EAF2 (ELL associated factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Eaf in Genome Data Viewer
    Location:
    43B2-43B2; 2-56 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7396850..7407819, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3284355..3295324, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene DEAH-box helicase 15 Neighboring gene antisense RNA:CR44201 Neighboring gene Gustatory receptor 43a Neighboring gene Glyoxalase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-4977 stem loop Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44202 Neighboring gene sine oculis

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL. Smith ER, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18562276, Free PMC Article
    2. Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. Campos I, et al. Genetics, 2010 Jan. PMID 19884309, Free PMC Article
    3. A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability. Fisher KH, et al. J Cell Sci, 2018 Jul 6. PMID 29848658, Free PMC Article
    4. Epigenetic Regulation of ALS and CMT: A Lesson from Drosophila Models. Yamaguchi M, et al. Int J Mol Sci, 2021 Jan 6. PMID 33419039, Free PMC Article
    5. The little elongation complex regulates small nuclear RNA transcription. Smith ER, et al. Mol Cell, 2011 Dec 23. PMID 22195968, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wound healing HMP PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm HDA PubMed 
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of super elongation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of super elongation complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription elongation factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ELL-associated factor
    Names
    CG11166-PA
    CG11166-PB
    CG11166-PC
    CG11166-PD
    Eaf-PA
    Eaf-PB
    Eaf-PC
    Eaf-PD
    dELL-associated factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7396850..7407819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136429.4 → NP_610273.1  ELL-associated factor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610273.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JGZ1, Q7JRJ1, Q86PA3
      Related
      FBpp0088079
      Conserved Domains (1) summary
      pfam09816
      Location:22 → 122
      EAF; RNA polymerase II transcription elongation factor

    2. NM_165521.3 → NP_724550.1  ELL-associated factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724550.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JRJ1
      Related
      FBpp0088081
      Conserved Domains (1) summary
      pfam09816
      Location:8 → 68
      EAF; RNA polymerase II transcription elongation factor

    3. NM_165518.3 → NP_724547.1  ELL-associated factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JGZ1, Q7JRJ1, Q86PA3
      Related
      FBpp0088080
      Conserved Domains (1) summary
      pfam09816
      Location:22 → 122
      EAF; RNA polymerase II transcription elongation factor

    4. NM_165519.3 → NP_724548.1  ELL-associated factor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724548.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JGZ1, Q7JRJ1, Q86PA3
      Related
      FBpp0088078
      Conserved Domains (1) summary
      pfam09816
      Location:22 → 122
      EAF; RNA polymerase II transcription elongation factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JRJ1.1 Q7JRJ1

    Gene LinkOut

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