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    CG30495 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246651, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG30495provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050495
    Locus tag
    Dmel_CG30495
    See related
    AllianceGenome:FB:FBgn0050495
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17986; Dmel\CG30495
    Summary
    Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity. Predicted to be involved in retinal metabolic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 13 and Leber hereditary optic neuropathy. Orthologous to several human genes including RDH13 (retinol dehydrogenase 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG30495 in Genome Data Viewer
    Location:
    43E7-43E8; 2-57 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7656895..7659061)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3544400..3546566)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 1 Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor-like 43a Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster. Belyaeva OV, et al. Biochim Biophys Acta, 2009 Oct. PMID 19520149, Free PMC Article
    2. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article
    3. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    4. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article
    5. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in retinal metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG30495-PA
    CG30495-PB
    NP_001260785.1
    NP_724589.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7656895..7659061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273856.1 → NP_001260785.1  uncharacterized protein Dmel_CG30495, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260785.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFB3, Q4QQ95
      Conserved Domains (2) summary
      COG1028
      Location:44 → 296
      FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl21454
      Location:45 → 323
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_165548.4 → NP_724589.2  uncharacterized protein Dmel_CG30495, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724589.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z726, Q4QQ95
      Conserved Domains (2) summary
      COG1028
      Location:44 → 292
      FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl21454
      Location:45 → 319
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFB3 A0A0B4KFB3
    A1Z726 A1Z726

    Gene LinkOut

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