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    FANCI Fanconi anemia complementation group I [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FANCIprovided by FlyBase
    Official Full Name
    Fanconi anemia complementation group Iprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033354
    Locus tag
    Dmel_CG13745
    See related
    AllianceGenome:FB:FBgn0033354
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13745; Dmel\CG13745; fanci
    Summary
    Predicted to enable DNA polymerase binding activity. Predicted to be involved in DNA repair. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group I; and female breast cancer. Orthologous to human FANCI (FA complementation group I). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See FANCI in Genome Data Viewer
    Location:
    44F9-44F9; 2-59 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8934576..8939789, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4822081..4827294, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Poly(A)-binding protein-dependent poly(A) ribonuclease 2 Neighboring gene Baramicin B Neighboring gene long non-coding RNA:CR44273 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The structure of the catalytic subunit FANCL of the Fanconi anemia core complex. Cole AR, et al. Nat Struct Mol Biol, 2010 Mar. PMID 20154706, Free PMC Article
    2. Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2. Bretscher HS, et al. Dev Cell, 2016 Jun 6. PMID 27270041, Free PMC Article
    3. Sustained inactivation of the Polycomb PRC1 complex induces DNA repair defects and genomic instability in epigenetic tumors. Rawal CC, et al. Histochem Cell Biol, 2024 Jul. PMID 38888809, Free PMC Article
    4. The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila. Sieber MH, et al. Cell Metab, 2009 Dec. PMID 19945405, Free PMC Article
    5. Effect of Larval Nutrition on Maternal mRNA Contribution to the Drosophila Egg. Crofton AE, et al. G3 (Bethesda), 2018 May 31. PMID 29666195, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA polymerase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fanconi anemia complementation group I
    Names
    CG13745-PA
    FANCI-PA
    fanconi anemia complementation group I homologue

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8934576..8939789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136585.3 → NP_610429.2  fanconi anemia complementation group I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610429.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7L1
      UniProtKB/TrEMBL
      Q29QV6
      Conserved Domains (1) summary
      cd11720
      Location:37 → 1293
      FANCI; Fanconi anemia I protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7L1 A1Z7L1

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